Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11bGr-1 Myeloid-derived Suppressor Cells.

Immune Network
Jung-Mi LeeChang-Yuil Kang

Abstract

CD137 (4-1BB/tnfrsf9) has been shown to co-stimulate T cells. However, agonistic anti-CD137 monoclonal antibody (mAb) treatment can suppress CD4(+) T cells, ameliorating autoimmune diseases, whereas it induces activation of CD8(+) T cells, resulting in diverse therapeutic activity in cancer, viral infection. To investigate the CD137-mediated T cell suppression mechanism, we examined whether anti-CD137 mAb treatment could affect CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs). Intriguingly, anti-CD137 mAb injection significantly increased CD11b(+)Gr-1(+) cells, peaking at days 5 to 10 and continuing for at least 25 days. Furthermore, this cell population could suppress both CD8(+) T cells and CD4(+) T cells. Thus, this study demonstrated that, for the first time, anti-CD137 mAb treatment could induce CD11b(+)Gr-1(+) MDSCs under normal conditions, suggesting a possible relationship between myeloid cell induction and CD137-mediated immune suppression.

References

Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yonglian SunYang-Xin Fu
May 22, 2002·Nature Immunology·E Scott HalsteadPeter D Katsikis
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert E MillerDavid H Lynch
Mar 3, 2004·International Journal of Cancer. Journal International Du Cancer·Dongping XuShu-Hsia Chen
Sep 28, 2004·Nature Medicine·Su K SeoByoung S Kwon
Aug 23, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dass S VinayByoung S Kwon
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liguo NiuRobert S Mittler
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
May 12, 2009·Immunological Reviews·Chao WangTania H Watts
Jun 6, 2009·European Journal of Immunology·Dass S VinayByoung S Kwon

❮ Previous
Next ❯

Citations

Apr 23, 2020·Journal of Medicinal Food·Won-Kyung YangYang-Chun Park

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
S WangX Wu
© 2021 Meta ULC. All rights reserved