Agranulocytosis, aplastic anemia, and leukemia: relevance to arachidonic acid metabolism

Prostaglandins, Leukotrienes, and Essential Fatty Acids
U N Das

Abstract

Several agents including drugs, chemicals and viruses are known to induce agranulocytosis, aplastic anemia, and leukemia. The recent identification, characterization and cloning of several peptide regulatory factors, including granulocyte-macrophage-colony stimulating peptide regulatory factor (GM-CSF), erythropoietin, and interleukins and a study of their actions, suggest that agents producing agranulocytosis, aplastic anemia, and leukemia may interfere with the action of these factors. The agents that are capable of inducing these diseases and the various peptide regulatory factors have positive and/or negative actions on the prostaglandin system. Prostaglandins are known to be involved in the maturation and differentiation of the progenitor cells of the bone marrow and in erythropoietin-mediated erythropoiesis. Since prostaglandins influence immune response, modify genetic damage induced by drugs and chemicals, modulate gene action, and have feed-back control on the actions of peptic regulatory factors, it is likely that prostaglandins are involved in the pathogenesis of agranulocytosis, aplastic anemia, and leukemia. If so, this may lead to new therapeutic strategies in these hematological conditions.

References

Mar 27, 1976·Lancet·J AscensãoR Good
May 20, 1978·Lancet·S A Weitzman, T P Stossel
Jul 1, 1978·Lancet·A MorleyJ Sorrell
Feb 1, 1978·Postgraduate Medical Journal·N NagaratnamS Rajiyah
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May 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Metcalf

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Citations

Sep 1, 1995·Postgraduate Medical Journal·P D Forsyth, J M Davies
Feb 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R KoratkarN Madhavi

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