Agranulocytosis associated with lamotrigine in a patient with low-grade glioma

Epilepsia
Camilo E FadulLionel D Lewis

Abstract

To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor. A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously. After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved. In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.

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Citations

Jan 11, 2008·Primary Care Companion to the Journal of Clinical Psychiatry·Piyush DasTeri L Gabel
Oct 17, 2007·The Psychiatric Clinics of North America·Madeleine BeckerElisabeth J Shakin Kunkel
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