Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis

Acta Haematologica
I E BurtonP A Sanders

Abstract

Agranulocytosis and septicaemia developing in a patient with rheumatoid arthritis after 3 years' intermittent treatment with diclofenac, cimetidine and flucloxacillin for staphylococcal osteomyelitis is described. Treatment with recombinant granulocyte-colony-stimulating factor and high-dose methylprednisolone had no effect on the neutropenia which resolved on stopping all drug therapy. Relapse of agranulocytosis followed reintroduction of flucloxacillin and cimetidine 3 months later.

Citations

Jan 27, 2005·Journal of Paediatrics and Child Health·J van den BoomN S Stott
Mar 21, 2006·Journal of the American Academy of Dermatology·Abdulmajeed AlajlanIssam R Hamadah
Feb 18, 2010·Medicinal Research Reviews·Eleni Pontiki, Dimitra Hadjipavlou-Litina

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