Agreement and repeatability of vascular reactivity estimates based on a breath-hold task and a resting state scan

NeuroImage
I LippRichard G Wise

Abstract

FMRI BOLD responses to changes in neural activity are influenced by the reactivity of the vasculature. By complementing a task-related BOLD acquisition with a vascular reactivity measure obtained through breath-holding or hypercapnia, this unwanted variance can be statistically reduced in the BOLD responses of interest. Recently, it has been suggested that vascular reactivity can also be estimated using a resting state scan. This study aimed to compare three breath-hold based analysis approaches (block design, sine-cosine regressor and CO2 regressor) and a resting state approach (CO2 regressor) to measure vascular reactivity. We tested BOLD variance explained by the model and repeatability of the measures. Fifteen healthy participants underwent a breath-hold task and a resting state scan with end-tidal CO2 being recorded during both. Vascular reactivity was defined as CO2-related BOLD percent signal change/mmHg change in CO2. Maps and regional vascular reactivity estimates showed high repeatability when the breath-hold task was used. Repeatability and variance explained by the CO2 trace regressor were lower for the resting state data based approach, which resulted in highly variable measures of vascular reactivity. We conclude ...Continue Reading

References

Dec 4, 1998·Stroke; a Journal of Cerebral Circulation·A KastrupM E Moseley
Aug 3, 2000·Neuroreport·R B BanzettL Adams
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
May 29, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Axel RieckerAndreas Kastrup
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
Apr 6, 2005·NeuroImage·Moriah E ThomasonGary H Glover
May 4, 2006·Human Brain Mapping·Moriah E ThomasonGary H Glover
Nov 10, 2006·Human Brain Mapping·Daniel A HandwerkerMark D'Esposito
Oct 2, 2007·NeuroImage·Moriah E Thomason, Gary H Glover
Mar 18, 2008·NeuroImage·Sridhar S Kannurpatti, Bharat B Biswal
Oct 28, 2008·NeuroImage·Catie ChangGary H Glover
Jan 27, 2009·NeuroImage·Alejandro CaceresMitul A Mehta
Feb 13, 2009·NeuroImage·Stefano MagonAndrea Sbarbati
May 18, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn P van den Heuvel, Hilleke E Hulshoff Pol
Mar 13, 2012·Frontiers in Systems Neuroscience·Sridhar S KannurpattiBharat B Biswal
Mar 31, 2012·Human Brain Mapping·Peiying LiuHanzhang Lu

❮ Previous
Next ❯

Citations

Apr 26, 2016·Brain and Behavior·Christiaan Hendrik Bas van NiftrikJorn Fierstra
Aug 14, 2015·Journal of Magnetic Resonance Imaging : JMRI·Harshan RaviHanzhang Lu
Sep 30, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hesamoddin JahanianUNKNOWN SPRINT Study Research Group
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manus J DonahueBlaise deB Frederick
Sep 12, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lauri RaitamaaVesa Kiviniemi
Sep 2, 2017·Scientific Reports·Douglas D GarrettClaudine J Gauthier
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kamen A TsvetanovJames B Rowe
Feb 5, 2021·Frontiers in Physiology·Joana PintoPatrícia Figueiredo
Mar 9, 2021·Frontiers in Physiology·Sergio M Solis-BarqueroMaría A Fernández-Seara
Apr 10, 2021·Frontiers in Neurology·Eleftherios KavroulakisEfrosini Papadaki
Jun 8, 2018·Journal of Neuroscience Methods·Adam L UrbackBenjamin I Goldstein
Nov 23, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Moss Y ZhaoGreg Zaharchuk

❮ Previous
Next ❯

Software Mentioned

FEAT ( FMRIB Expert Analysis Tool
PRELUDE FUGUE
FEAT
PickAtlas
MATLAB
AFNI
FLIRT
BET
MCFLIRT
WFU

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.