Agreement between Quantiferon-TB gold test and tuberculin skin test in the identification of latent tuberculosis infection in patients with rheumatoid arthritis and ankylosing spondylitis

The Journal of Rheumatology
Nevsun InancHaner Direskeneli

Abstract

To compare the Quantiferon-TB Gold test (QTF-G) with the tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) among patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS), with reevaluation of the patients treated with tumor necrosis factor-alpha (TNF-alpha) antagonists in the followup. The study involved 140 consecutive patients, 82 with RA and 58 with AS. Thirty patients were evaluated with QTF-G for detection of LTBI before and after 6 months of TNF-alpha antagonist treatment. QTF-G was also performed on 49 healthy controls. QTF-G results were recorded as positive, negative, or indeterminate. A positive TST was defined as >or= 5 mm for RA and AS. The percentages of positive QTF-G were comparable in RA and AS (37% vs 32%). The rate of positive QTF-G in healthy controls (29%) was also similar to RA and AS. In contrast to QTF-G results, a high rate of TST positivity was observed in AS compared to RA (82% vs 55%; p = 0.02). The total agreement between QTF-G and TST was observed to be 61% (kappa = 0.29) in the whole group, 70% (kappa = 0.42) in RA, and 49% (kappa = 0.14) in AS. After 6 months of treatment with TNF-alpha antagonists, a high rate of QTF-G change was observed in patie...Continue Reading

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Citations

Jun 6, 2012·International Journal of Rheumatology·Esko TavastMarjatta Lerisalo-Repo
Oct 11, 2014·American Journal of Respiratory and Critical Care Medicine·Martina SesterUNKNOWN TBNET
Apr 30, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tomoyo MaedaRyzo Ueda
Jul 19, 2015·Archivos de bronconeumología·Isabel Mir ViladrichJosé Maria García García
May 21, 2011·Expert Review of Clinical Immunology·Eva Salgado, Juan J Gómez-Reino
Aug 1, 2019·Open Forum Infectious Diseases·Jonathan W UzorkaSandra M Arend
Jun 25, 2017·World Journal of Pediatrics : WJP·Francesca GabrieleEmmanuel Roilides

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