PMID: 11903430Mar 21, 2002Paper

Agreement between troponin T levels from plain and heparinized tubes

Emergency Medicine
P G JonesG Gamble

Abstract

To determine whether there was a clinically significant effect on troponin T measurement when the sample was collected in a heparinized (plasma) blood collection tube compared with a serum tube. Prospective cohort study using a convenience sample of 198 patients with undifferentiated illness presenting to an Emergency Department who required troponin T measurement. Samples were collected in both plain (serum) tubes and plasma tubes for comparison. All samples were measured using an Elecsys 2010 Immunoassay system (Roche-Boehringer Mannheim, Germany). There were 35 troponin T measurements > or = 0.03 microg/L (the limit of reproducibility of the test). The negative predictive value for troponin T performed in heparinized tubes compared with plain tubes was 100% (95% confidence interval 96.4-100) at the > or = 0.03 microg/L level and 100% (95% confidence interval 97-100%) at the > or = 0.1 microg/L level. At a cut-off point for risk stratification in acute coronary syndromes (> or = 0.1 microg/L), there was 100% concordance between the two measurements for each sample. The use of plasma (heparinized) tubes for the collection of troponin T samples is unlikely to produce clinically significant false-negative results compared with c...Continue Reading

References

Dec 3, 1999·BMJ : British Medical Journal·G S Hillis, K A Fox
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·F HartmannH A Katus
Mar 23, 2000·The American Journal of Cardiology·E S McErleanS E Nissen
Sep 12, 2000·Circulation·A S JaffeH Katus

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