Agreement of serum Spec cPL with the 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assay and with pancreatic ultrasonography in dogs with suspected pancreatitis

Journal of Veterinary Internal Medicine
P H KookC E Reusch

Abstract

Spec cPL is the most sensitive and specific test for diagnosing pancreatitis in dogs. Its results have not been compared to those of the 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assay or those of abdominal ultrasonography. To investigate agreement of Spec cPL with DGGR lipase activity and pancreatic ultrasonography in dogs with suspected pancreatitis. One hundred and forty-two dogs. DGGR lipase activity (reference range, 24-108 U/L) and Spec cPL were measured using the same sample. The time interval between ultrasonography and lipase determinations was <24 hours. The agreement of the 2 lipase assays at different cutoffs and the agreement between pancreatic ultrasonography and the 2 tests were assessed using Cohen's kappa coefficient (κ). DGGR lipase (>108, >216 U/L) and Spec cPL (>200 μg/L) had κ values of 0.79 (95% confidence interval [CI], 0.69-0.9) and 0.70 (CI, 0.58-0.82). DGGR lipase (>108, >216 U/L) and Spec cPL (>400 μg/L) had κ values of 0.55 (CI, 0.43-0.67) and κ of 0.80 (CI, 0.71-0.9). An ultrasonographic diagnosis of pancreatitis and DGGR lipase (>108, >216 U/L) had κ values of 0.29 (CI, 0.14-0.44) and 0.35 (CI, 0.18-0.52). Ultrasonographically diagnosed pancreatitis and Spe...Continue Reading

References

Mar 7, 2002·Ultrasound in Medicine & Biology·Francis A Duck
May 16, 2002·The Veterinary Clinics of North America. Small Animal Practice·Petra A Volmer, Gavin L Meerdink
Oct 14, 2003·The Veterinary Clinics of North America. Small Animal Practice·Jörg M Steiner
Sep 12, 2007·Clinical Techniques in Small Animal Practice·Silke Hecht, George Henry
Feb 5, 2008·American Journal of Veterinary Research·Daniel A FeeneyRobert M Hardy
Jun 30, 2010·Journal of Veterinary Internal Medicine·A E JergensC Wang
Mar 1, 2011·Acta Veterinaria Hungarica·Kinga PápaKároly Vörös
Aug 7, 2012·Veterinary Clinical Pathology·Panagiotis G Xenoulis, Jörg M Steiner
Feb 27, 2013·American Journal of Veterinary Research·Dominique G PenninckCynthia R Webster

❮ Previous
Next ❯

Citations

Mar 10, 2016·The Veterinary Journal·Jonathan A Lidbury, Jan S Suchodolski
Jan 15, 2015·The Journal of Small Animal Practice·P G Xenoulis
Jan 15, 2015·The Journal of Small Animal Practice·Penny Watson
Mar 3, 2018·Journal of Veterinary Internal Medicine·Michael BennaimCarmel T Mooney
Feb 17, 2019·Journal of Veterinary Internal Medicine·Virginie FabrèsGhita Benchekroun
May 9, 2016·Journal of Veterinary Internal Medicine·T A BoltonG T Fosgate
Nov 5, 2020·Journal of Veterinary Internal Medicine·Beatriz MendozaRodolfo Oliveira Leal
Apr 3, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Gonçalo SerranoPenny Watson
Jun 4, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Guido LinariFederico Fracassi
Jul 2, 2021·Journal of Veterinary Internal Medicine·Kristen HamiltonChen Gilor
Sep 30, 2021·Veterinary Clinical Pathology
Nov 10, 2021·Journal of Veterinary Internal Medicine·Harry CridgeJörg M Steiner

❮ Previous
Next ❯

Methods Mentioned

BETA
lipase assay
lipase

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.