Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice.

International Immunopharmacology
Jinjin CaoHong-Bing Wang

Abstract

Excessive activity of osteoclasts causes many bone-related diseases, such as rheumatoid arthritis and osteoporosis. Agrimophol (AGR), a phenolic compound, originated from Agrimonia pilosa Ledeb. In prior studies, AGR is reported to possess schistosomicidal and mycobactericidal activities. However, no reports covered its anti-osteoclastogenesis characteristic. In this study, we found that AGR inhibited RANKL-induced osteoclastogenesis, bone-resorption, F-actin ring formation, and the mRNA expression of osteoclast-associated genes such as CTSK, TRAP, MMP-9, and ATP6v0d2 in vitro. In addition, AGR suppressed RANKL-induced expression of c-Fos and NFATc1. However, AGR treatment did not affect NF-κB activation and MAPKs phosphorylation in RANKL-stimulated BMMs, which implicated that AGR might not influence the initial expression of NFATc1 mediated by NF-κB and MAPKs signaling. Our results further indicated that AGR did not alter phosphorylation levels of GSK3β and the expression of calcineurin, which implicated that AGR treatment might not interfere with phosphorylation and de-phosphorylation of NFATc1 mediated by GSK3β and calcineurin, respectively. B-lymphocyte-induced maturation protein-1 (Blimp1), which was regarded as a transcri...Continue Reading

References

May 2, 2000·The Journal of Biological Chemistry·P Gómez del ArcoJ M Redondo
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M ZaidiE Abe
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jul 23, 2003·Development·Céline ColnotJill A Helms
Jun 14, 2005·Archives of Biochemistry and Biophysics·Natasa MitićGerhard Schenk
Oct 21, 2006·The Journal of Clinical Investigation·Dailing MaoRoberta Faccio
Feb 2, 2008·Archives of Biochemistry and Biophysics·Andrea Del FattoreNadia Rucci
Feb 26, 2008·European Journal of Cell Biology·Frédéric SaltelPierre Jurdic
Oct 11, 2008·The Journal of Clinical Investigation·Antonios O AliprantisLaurie H Glimcher
Sep 17, 2009·Immunological Reviews·Takako Negishi-Koga, Hiroshi Takayanagi
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Keizo NishikawaHiroshi Takayanagi
Apr 7, 2010·The Journal of Experimental Medicine·Yoshiteru MiyauchiTakeshi Miyamoto
Sep 29, 2011·The Journal of Biological Chemistry·Hyun Duk JangSoo Young Lee
Oct 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Masashi NagaoMasaki Noda
Dec 28, 2011·The Keio Journal of Medicine·Takeshi Miyamoto
Mar 29, 2012·Advances in Experimental Medicine and Biology·Hiroshi Kajiya
Feb 20, 2013·Bone·Hyun Duk JangSoo Young Lee
Mar 8, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y Abu-Amer
Jul 1, 2014·Archives of Biochemistry and Biophysics·Alfredo CapparielloAnna Teti
Dec 10, 2014·Journal of Bone Metabolism·Jung Ha Kim, Nacksung Kim
Oct 14, 2016·International Journal of Molecular Sciences·Shangfu LiLimin Rong
May 23, 2017·The Journal of Clinical Investigation·Joseph Lorenzo
Jun 3, 2017·International Immunopharmacology·Jinjin CaoWan-Chun Sun
Jul 27, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahesh SapkotaYunjo Soh
Jun 13, 2019·Nature Reviews. Immunology·Masayuki Tsukasaki, Hiroshi Takayanagi

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