PMID: 8587694Jul 1, 1995Paper

Agrin: toward a molecular understanding of synapse regeneration

Neurosurgery
K A DeystJ R Fallon

Abstract

One of the foremost challenges to repairing damage after stroke, trauma, or disease is the regeneration of synaptic connections between neurons. Here, we consider recent strides in our understanding of the molecular basis of synapse formation and regeneration. We will focus on the protein agrin, a key player in synaptogenesis at neuromuscular junctions and perhaps at central nervous system synapses as well. Insights into agrin and its receptor could guide the development of rational therapies to combat neuronal degeneration. We will also consider recent surprising and provocative data linking the mechanisms of synapse formation and the cellular pathology in Duchenne muscular dystrophy.

References

Apr 1, 1992·Neuron·K W TsimU J McMahan
Jul 1, 1992·Journal of Neurobiology·B G Wallace
Oct 1, 1992·The Journal of Cell Biology·T S KhuranaL M Kunkel
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T W KimI B Black
Jul 1, 1991·The Journal of Cell Biology·V WitzemannB Sakmann
May 1, 1991·Neuron·F RuppR H Scheller
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·U J McMahan
Jan 1, 1991·The Journal of Cell Biology·K OhlendieckK P Campbell
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Mar 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R W Olsen, A J Tobin
Jan 1, 1990·Advances in Experimental Medicine and Biology·S J TapscottH Weintraub
Dec 1, 1987·The Journal of Cell Biology·R M NitkinU J McMahan
Nov 1, 1988·The Journal of Cell Biology·C Magill-Solc, U J McMahan
Nov 1, 1994·Trends in Neurosciences·J R Fallon, Z W Hall
Jan 1, 1995·Annual Review of Neuroscience·M A Bowe, J R Fallon
Feb 1, 1993·Trends in Neurosciences·M A Nastuk, J R Fallon
Feb 1, 1993·Trends in Neurosciences·L Patthy, K Nikolics
Jan 1, 1993·Annual Review of Neuroscience·P B Sargent
Sep 1, 1994·Human Molecular Genetics·D C GóreckiE A Barnard
Apr 1, 1993·Nature Genetics·A H Ahn, L M Kunkel
Jul 1, 1994·Neuron·J SugiyamaZ W Hall
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M TinsleyK E Davies
Jan 1, 1993·Annual Review of Neuroscience·S G Amara, M J Kuhar

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Citations

Dec 1, 1996·Journal of Neurocytology·R E Schmidt
Jan 26, 2017·Neural Plasticity·Xiaoling LuHuawei Li

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