AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

The British Journal of Radiology
François LuxOlivier Tillement

Abstract

AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.

Associated Clinical Trials

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Citations

Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
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Methods Mentioned

BETA
dynamic light scattering
X-ray
xenograft
fluorescence imaging
irradiating

Clinical Trials Mentioned

NCT02820454
NCT03308604

Software Mentioned

MagForce
NanoRAD

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