AGuIX nanoparticles as a promising platform for image-guided radiation therapy

Cancer Nanotechnology
Alexandre DetappeRoss Berbeco

Abstract

AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as a radiosensitizer. We used MRI to quantify the uptake of AGuIX in pancreatic cancer cells, and TEM for intracellular localization. We measured the radiosensitization of a pancreatic cancer cell line in a low-energy (220 kVp) beam, a standard 6 MV beam (STD) and a flattening filter free 6 MV beam (FFF). We demonstrated that the presence of nanoparticles significantly decreases cell survival when combined with an X-ray beam with a large proportion of low-energy photons (close to the k-edge of the nanoparticles). The concentration of nanoparticles in the cell achieves its highest level after 15 min and then reaches a plateau. The accumulated nanoparticles are mainly localized in the cytoplasm, inside vesicles. We found that the 6 MV FFF beams offer the best trade-off between penetration depth and proportion of low-energy photons. At 10 cm depth, we measured a DEF20 % of 1.30 ± 0.47 for the 6 MV FFF beam, compared to 1.23 ± 0.26 for the 6 MV STD beam. Additional measurements with un-incubated nanoparticles provide evidence that chemical processes might also be contributin...Continue Reading

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Citations

Apr 14, 2016·Nanomedicine·Alexandre DetappeOlivier Tillement
Jun 9, 2016·Molecular Pharmaceutics·Charles TruilletMichael J Evans
Jul 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexandre DetappeRoss Berbeco
Sep 24, 2016·Scientific Reports·Alexandre DetappeRoss Berbeco
Feb 17, 2018·Nature Reviews. Cancer·Wilfred NgwaSilvia C Formenti
Jun 22, 2017·Physics in Medicine and Biology·Syed Bilal AhmadBrian M Keller
Oct 16, 2016·Macromolecular Bioscience·Peng MiHoracio Cabral
Nov 11, 2017·Physics in Medicine and Biology·Zdenka Kuncic, Sandrine Lacombe
Dec 13, 2019·Frontiers in Bioengineering and Biotechnology·Pengcheng HuDengfeng Cheng
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Oct 4, 2017·Frontiers in Oncology·Wilfred NgwaAllen Herman
Jun 20, 2019·EJNMMI Physics·Olga KochebinaDavid Sarrut
Jul 8, 2020·International Journal of Radiation Oncology, Biology, Physics·Alexandre DetappePeter P Ghoroghchian
Jan 12, 2021·International Journal of Radiation Biology·Joseph Byung-Kyu KimSunil Krishnan
Aug 4, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·L MaigneH Payno

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Methods Mentioned

BETA
X-ray
irradiating
dynamic light scattering

Software Mentioned

AGuIX
EGSnrc

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