Ahnak/Desmoyokin is dispensable for proliferation, differentiation, and maintenance of integrity in mouse epidermis

The Journal of Investigative Dermatology
Michiyoshi KounoTakashi Hashimoto

Abstract

Desmoyokin was first isolated from bovine muzzle epidermis and thought to be an epidermal desmosome-related protein. We previously demonstrated that the Desmoyokin gene is identical to the Ahnak gene, which is expressed ubiquitously and downregulated in neuroblastomas. It was assumed Ahnak/Desmoyokin was associated with epidermal cell adhesion, tumorigenesis, cell proliferation and differentiation, and embryonic development. To determine the precise biological function of Ahnak/Desmoyokin, we generated a null mutation in ES cells and mice. The resultant Ahnak/Desmoyokin-deficient ES cells normally differentiated into embryoid bodies and neural cells. The mutant mice were viable and fertile and showed no gross developmental defects. Electron microscopic examination of skin sections demonstrated that the ultrastructure of epidermal intercellular junctions, including desmosomes, of the mutant mice was indistinguishable from that of wild-type mice. Two-stage chemical skin carcinogenesis experiments showed no difference in frequency or onset of cutaneous tumor formation between wild-type and mutant mice. Moreover, no tumorigenesis was observed in other tissues and organs of mutant mice up to 2 y of age. These results lead us to conc...Continue Reading

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Citations

Sep 29, 2011·The Journal of Biological Chemistry·Atoosa RezvanpourGary S Shaw
Sep 14, 2010·Biochemical and Biophysical Research Communications·Andreas MargIngo Morano
Sep 18, 2004·The Journal of Investigative Dermatology·Masayuki Amagai
Jun 14, 2012·The Journal of Pathology·Takashi HashimotoMinao Furumura
Nov 26, 2010·Biochemical and Biophysical Research Communications·Il Yong KimGeum-Sook Hwang
Jan 7, 2015·Journal of Cellular Biochemistry·Aleksandr KirovIgor Prudovsky
Jan 28, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alicia BáezÁlvaro Urbano-Ispizua
May 4, 2017·Journal of Vascular Research·Nadine HaaseTobias Haase
Jul 8, 2010·Pflügers Archiv : European journal of physiology·Julio L AlvarezHannelore Haase
Nov 1, 2011·Journal of Muscle Research and Cell Motility·Ines PankonienHannelore Haase
Mar 8, 2011·Experimental Dermatology·Yongoua SandjeuMarek Haftek
Jan 31, 2018·Experimental Dermatology·Shreya BhattacharyaMaria I Morasso

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