PMID: 45570Jan 1, 1979

AHR-6646: a new, long-acting neuroleptic

Progress in Neuro-psychopharmacology
D N JohnsonW H Funderburk

Abstract

1. AHR-6646 blocked d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval was between one hour and seven days. 2. Conditioned avoidance responding in mice and cats was suppressed by AHR-6646 in doses that did not impair escape behavior. The duration of this effect was markedly prolonged. 3. AHR-6646 produced catalepsy in rats. The onset of this effect was delayed and the duration was prolonged when compared with that of chlorpromazine. 4. Apomorphine-induced pivoting in mice with unilateral lesions of the caudate nucleus was suppressed by AHR-6646. 5. AHR-6646 was a potent antiemetic agent in dogs, with a delayed onset and prolonged duration of action.

References

Jan 1, 1984·Molecular Aspects of Medicine·J H Barnes

Citations

Jul 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·V J Lotti
Dec 18, 1971·British Medical Journal·H M van PraagR van Schilfgaarden

Related Concepts

Antipsychotic Effect
Behavior, Animal
Antiemetics
Aggregation
Catalepsy
Antipsychotic Agents
Drug Interactions
Chlorpromazine
Caudate Nucleus Structure
AHR 6646

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