Abstract
DNA breaks caused by recombination-activating gene 1 (RAG1) and activation-induced cytidine deaminase (AID) induce c-myc/immunoglobulin (Ig) heavy chain chromosomal translocations and thereby stimulate lymphomagenesis. However, constitutive expression of c-myc alone is not sufficient to induce lymphomas. Because RAG1 and AID activity occurs outside of Ig genes, we assessed whether these enzymes provide the secondary genetic lesions in Emu c-myc transgenic mice to promote lymphoma development. We found that the tumor incidence and tumor phenotype in Emu c-myc transgenic mice is similar in AID+/+, AID+/- and AID-/- backgrounds in both specific pathogen-free and conventional animal facilities, indicating that AID does not contribute to lymphoma development in Emu c-myc transgenic mice. To examine the role of RAG proteins in Emu c-myc mice, we examined Emu c-myc transgenic mice that harbor the Ig-HEL heavy- and light-chain transgenes, and thus have reduced RAG expression in B cells. We found that tumor incidence was not affected by these Ig transgenes. However, we found that RAG1-/- Emu c-myc mice exhibited accelerated tumor development compared to controls. This data combined with our finding that Emu c-myc mice lived longer in th...Continue Reading
References
Jan 1, 1992·Annual Review of Immunology·S J Korsmeyer
Feb 1, 1992·International Immunology·D Y MasonC C Goodnow
May 31, 1991·Cell·M van LohuizenA Berns
Feb 1, 1988·The Journal of Experimental Medicine·A W HarrisJ M Adams
Aug 25, 1988·Nature·C C GoodnowK Raphael
Dec 12, 1985·Nature·J M AdamsR L Brinster
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce
Dec 24, 1982·Science·S CrewsK Calame
Feb 1, 1996·Cytometry·V S PrasadC L Sidman
Jun 20, 1998·Science·H M ShenU Storb
Aug 11, 1998·Immunity·W FangT W Behrens
Jun 22, 1999·The Journal of Biological Chemistry·M MuramatsuT Honjo
Oct 29, 1999·Genes & Development·C M EischenJ L Cleveland
Sep 28, 2000·Cell·M MuramatsuT Honjo
Dec 20, 2000·The Journal of Experimental Medicine·M MüschenR Küppers
Jul 19, 2001·Nature·L PasqualucciR Dalla-Favera
Mar 6, 2004·Nature·Sathees C RaghavanMichael R Lieber
Apr 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alexander EgleSuzanne Cory
Aug 19, 2004·Cell·Almudena R RamiroMichel C Nussenzweig
Feb 3, 2005·Oncogene·Darrin P SmithSuzanne Cory
Jan 10, 2006·Nature·Almudena R RamiroMichel C Nussenzweig
Jan 24, 2006·Molecular Cell·Sonia FrancoFrederick W Alt
Aug 29, 2006·DNA Repair·Sonia FrancoJohn P Manis
Jan 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ai KotaniTasuku Honjo
Mar 3, 2007·Annual Review of Biochemistry·Javier M Di Noia, Michael S Neuberger
Apr 25, 2007·The Journal of Experimental Medicine·Elizabeth E CrouchRafael Casellas
Aug 29, 2007·The Journal of Experimental Medicine·Yair DorsettMichel C Nussenzweig
Citations
Oct 30, 2010·Leukemia·V B T TaR W Hendriks
Jul 25, 2009·Nature Reviews. Immunology·David H Raulet, Nadia Guerra
May 5, 2010·Oncogene·L C OsborneN Abraham
Jun 1, 2011·Oncogene·M A W RowhC H Bassing
Oct 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rajeev M NepalAlberto Martin
Apr 21, 2012·Current Opinion in Hematology·Xiwen GuMatthew P Strout
May 19, 2012·PloS One·Sheryl M GoughPeter D Aplan
Jul 7, 2012·PloS One·Diane NamBenjamin Alman
Jun 7, 2013·PloS One·Antoaneta BelchevaAlberto Martin
Mar 13, 2014·The Journal of Clinical Investigation·Yuanzhi LuXianghong Zou
Sep 5, 2013·Molecular and Cellular Biology·Staci L PetersRene Opavsky
Oct 12, 2010·The American Journal of Pathology·Jonathan U PeledMatthew D Scharff
Mar 1, 2012·Experimental Hematology·Hongbing LiStuart A Berger
Jan 26, 2013·Blood·J Ludovic CroxfordStephan Gasser
May 31, 2011·Blood·Julia HauerMarina Cavazzana-Calvo
Dec 17, 2009·Blood·Van B T TaRudi W Hendriks
Aug 15, 2014·Frontiers in Immunology·Valentin S Bruttel, Jörg Wischhusen
Jul 26, 2018·Frontiers of Medicine·Sumedha Roy, Yuan Zhuang
Nov 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas K PreissEdward J Usherwood
Dec 29, 2020·PLoS Genetics·Pilar DelgadoAlmudena R Ramiro