AID is expressed in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas and is not correlated with intraclonal heterogeneity

Leukemia
I S LossosA A Alizadeh

Abstract

Activation-induced cytidine deaminase (AID), highly expressed in germinal center (GC)-lymphocytes, is involved in somatic hypermutation (SHM). We examined AID expression in diffuse large B-cell lymphomas (DLBCL) of germinal center B-cell (GCB)-like and activated B-cell (ABC)-like subtypes. These two types of DLBCL are characterized by high and low expression of GC-specific genes, respectively. AID expression was detected in both GCB- and ABC-like DLBCL, thus demonstrating a dissociation between AID expression and that of other GC genes. We also tested for the presence of intraclonal heterogeneity in immunoglobulin and BCL6 genes in those same tumors and in follicle center lymphomas (FCL) that transformed to DLBCL. The level of AID expression did not correlate with the presence of intraclonal sequence heterogeneity in either IgV(H) or BCL6. Our findings suggest that lymphomas maintain some but not all of the gene expression signatures of their normal B-cell counterparts. The fact that AID expression can be elevated without intraclonal sequence heterogeneity raises the possibility that other factors are required for SHM in these tumors. We found decreased levels of AID expression in DLBCL that evolved from FCL and which had acqui...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D W Bahler, R Levy
May 29, 1998·Immunological Reviews·U KleinR Küppers
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·L PasqualucciR Dalla-Favera
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·I S LossosR Levy
Dec 20, 2000·The Journal of Experimental Medicine·M MüschenR Küppers
Jun 18, 2002·Science·Kiyotsugu YoshikawaTasuku Honjo
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Jun 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Izidore S LossosRonald Levy
Jul 5, 2002·Nature·Svend K Petersen-MahrtMichael S Neuberger
Aug 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alberto Martin, Matthew D Scharff
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng ZhouKe Zhang

❮ Previous
Next ❯

Citations

Oct 13, 2006·Journal of Molecular Evolution·Jaroslav KubrychtPetr Jezek
Apr 28, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katsuyoshi TakataTadashi Yoshino
Oct 14, 2006·Leukemia·R J BendeC J M van Noesel
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Apr 21, 2012·Current Opinion in Hematology·Xiwen GuMatthew P Strout
Aug 30, 2005·Journal of Clinical Pathology·A MottokA Bräuninger
May 25, 2006·International Journal of Hematology·Kazuo Kinoshita, Taichiro Nonaka
Jun 13, 2012·Seminars in Immunology·Alexandre Orthwein, Javier M Di Noia
Jan 9, 2008·Leukemia Research·Anna Margrét HalldórsdóttirW Richard Burack
Oct 27, 2006·International Journal of Cancer. Journal International Du Cancer·Tadayuki KouTsutomu Chiba
Apr 22, 2014·DNA Repair·Hans E KrokanGeir Slupphaug
Sep 2, 2016·Chemical Reviews·Sachini U SiriwardenaAshok S Bhagwat
Nov 5, 2016·The Journal of Experimental Medicine·Elena M CortizasRamiro E Verdun
Sep 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Izidore S Lossos
Jan 18, 2018·Nature Communications·Matt TeaterRita Shaknovich
Mar 16, 2019·Immunological Reviews·Stefano CasolaFabio Facchetti
Jan 19, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Izidore S Lossos, Daniel Morgensztern
Jun 8, 2006·International Journal of Hematology·Jun-ichiro IkedaKatsuyuki Aozasa
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui-Chen HsuJohn D Mountz
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giorgio CattorettiBachir Alobeid
Nov 3, 2020·The Journal of Experimental Medicine·Xiaofei YeQiang Pan-Hammarström

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.