PMID: 20124634Feb 4, 2010Paper

AIDS and injecting drug use: survival determinants in the highly active antiretroviral therapy era

Epidemiologia e prevenzione
Antonella ZucchettoBarbara Suligoi

Abstract

to estimate survival, after AIDS diagnosis, in people who got infected with HIV through injecting drug use (IDUs), to identify among variables collected at AIDS diagnosis those which were associated to prognosis and to assess the frequency of morbid conditions at death. population-based, longitudinal study. 4,040 IDUs diagnosed with AIDS in Italy between 1999 and 2005. vital status up to 2006, was retrieved through a record-linkage procedure with italian mortality database. Kaplan-Meier method and multivariate Cox model were used to estimate survival curves and compute hazard ratios of death (HR), and corresponding 95% confidence intervals (95% CI), for several prognostic factors, respectively. the 2-year and 5-year survival probabilities after AIDS diagnosis of IDUs were 72% and 60%, respectively. Elevated risks of death emerged for IDUs with older ages (HR=2.0 95% CI 1.6-2.4 for>45 years old vs.<35 years old), lower education (HR=1.4 95% CI 1.2-1.7 for elementary school vs. high school/university), longer time span between first HIV positive test and AIDS diagnosis (HR=1.6 95% CI 1.4-1.9 for > 6 months vs. < 6 months), and lower CD4 cell count at diagnosis (HR=1.5 95% CI 1.3-1.7 for <50 cells/mm3 vs. > 200 cells/mm3). Compare...Continue Reading

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