AIDS incidence and AIDS-related mortality in British Columbia, Canada, between 1981 and 2013: a retrospective study

The Lancet. HIV
Viviane D LimaJulio S G Montaner

Abstract

Appropriate use of highly active antiretroviral therapy (ART) can substantially decrease the risk of progression to AIDS and of premature mortality. We aimed to characterise the trends between 1981 and 2013 in AIDS-defining illnesses (ADIs) and the number AIDS-related deaths in British Columbia, Canada, where ART has been fully subsidised since 1996. We included data on HIV-positive individuals, aged 19 years or older, from four administrative databases in British Columbia: the British Columbia Centre for Excellence in HIV/AIDS, St Paul's Hospital, the British Columbia Vital Statistics Agency, the British Columbia Cancer Agency. We estimated the relative risk of developing an ADI over time by use of a negative binomial model, and we investigated trends in the proportion of all deaths associated with AIDS by use of generalised additive models. Data were available for 3550 people with HIV. 6205 ADIs were recorded. In 2013, 84 ADIs occurred, the lowest number since 1990. The peak of the AIDS epidemic in the region happened in 1994 with 696 ADIs reported (42 ADIs per 100 person-years). Since 1997, the number of ADIs decreased from 253 (7 per 100 person-years) to 84 cases in 2013 (1 per 100 person-years; p<0·0001 for trend in number...Continue Reading

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Citations

Aug 25, 2015·Frontiers in Public Health·Alexey Karetnikov
Oct 2, 2015·The Lancet. HIV·Stefano Vella
Jun 16, 2016·Journal of Palliative Medicine·Steven Oppenheim
Jul 8, 2016·HIV Medicine·S KesselringUNKNOWN Canadian Observational Cohort Collaboration (CANOC)
Mar 31, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julia L MarcusMichael J Silverberg
Aug 16, 2016·PloS One·Adam TrickeyUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC)
Apr 23, 2017·Expert Review of Vaccines·Lorna LealFelipe García
Jan 16, 2018·Journal of the International AIDS Society·April C PettitUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC) investigators
Oct 11, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kiffer G CardDavid M Moore
Nov 9, 2018·Intensive Care Medicine·Anthony C Gordon, James A Russell
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Nov 16, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kristine M ErlandsonGiovanni Guaraldi
Nov 2, 2019·American Journal of Epidemiology·Pablo F Belaunzarán-ZamudioUNKNOWN Caribbean, Central and South America network for HIV epidemiology (CCASAnet)
May 26, 2020·Infectious Diseases of Poverty·Rui-Hua KangYu-Hua Ruan
Oct 7, 2018·Journal of Neurovirology·Ameer AbutalebEleanor Wilson
Jan 28, 2020·European Geriatric Medicine·Samuel F FreedmanTessa Del Carmen
Mar 4, 2020·Current HIV/AIDS Reports·Viviane D LimaUNKNOWN STOP HIV/AIDS Study Group
Nov 22, 2017·AIDS Research and Treatment·Marina NjelekelaDeodatus Kakoko
Nov 9, 2017·Journal of the International AIDS Society·Sahar SaeedUNKNOWN Canadian Co-Infection Cohort Study
Nov 14, 2017·Journal of the International AIDS Society·Viviane D LimaJulio S G Montaner
Mar 11, 2021·HIV/AIDS : Research and Palliative Care·Haddis BirhanuMolla Yigzaw Birhanu

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