AIDS-related lymphoma in Brazil. Histopathology, immunophenotype, and association with Epstein-Barr virus

American Journal of Clinical Pathology
C E BacchiA M Gown

Abstract

The occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several types of immunodeficiency-related lymphomas and Epstein-Barr virus (EBV), the association of EBV infection in AIDS-related lymphoma in Brazil, where the incidence of AIDS is high, is unknown. Formalin-fixed, paraffin-embedded tissue from 24 cases of AIDS-related lymphoma in Brazil were analyzed for morphologic classification, immunophenotype, and EBV association using in situ hybridization studies with an EBV-EBER1 biotinylated probe. Twenty cases of AIDS-related lymphoma were classified as non-Hodgkin's lymphoma and four cases were Hodgkin's disease. Eleven non-Hodgkin's lymphomas were classified as diffuse large cell type, five cases were small non-cleaved cell, Burkitt-type, and four cases were large cell immunoblastic non-Hodgkin's lymphoma. Eighteen cases were of B-cell phenotype; one was a T-cell lymphoma, and one was classified as null. Epstein-Barr virus (EBV) was demonstrated in the majority of tumor cells of ...Continue Reading

Citations

Jan 18, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Valeria I FinkUNKNOWN Caribbean Central South America Network for HIV Research Collaboration of the International Epidemiologic Databases to Evalu
Sep 1, 2007·Current Opinion in Oncology·Julio SampaioEduardo M Netto
Aug 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brenda Crabtree-RamírezJuan Sierra-Madero
Oct 17, 2014·BMC Gastroenterology·Carolina Rosal Teixeira de SouzaRommel Rodríguez Burbano
Jul 12, 2017·Tropical Doctor·Jagdeep S ThakurNarinder K Mohindroo
Nov 30, 2018·World Journal of Gastroenterology : WJG·Carolina Rosal Teixeira de SouzaRommel Mario Rodríguez Burbano
Oct 28, 1999·Archives of Pathology & Laboratory Medicine·D Elgui de OliveiraC E Bacchi
Aug 27, 2021·Oncotarget·Gyselle Ribeiro de Carvalho OliveiraRommel Rodriguez Burbano

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