AIDS therapy with two, three or four agent combinations, applied in short sequences, differing from each other by drug rotation. I. First of two parts: a phase I trial equivalent, concerning five virostatics: AZT, ddI, ddC, acriflavine and an ellipticine analogue

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
G MathéD Blanquet

Abstract

We have individually treated ten AIDS patients whose CD4 numbers were inferior to 200/mm3, with the five following HIV1 virostatics: a) azido-deoxythymidine (AZT), dideoxyinosine (ddI) and dideoxycytidine (ddC), which affect the same viral target, retrotranscriptase, b) acriflavine (ACF) and methyl-hydroxy-ellipticine (MHE) which we have discovered to be strong virostatics in vivo, in mice, against Friend's virus, and in man, against AZT resistant HIV1. We have shown that their combinations with AZT, hitting three viral targets, reduces in mice, the blood Friend's virus load below detectable level. Due to the short doubling time of HIV1, AIDS therapy must be continuous, and to allow the best tolerance, the five virostatic combinations were applied in short, three-week sequences, each differing as much as possible from the former and from the following one, due to drug rotation [1]. Among the ten patients, a) three received the two-drug combinations for 15 to 30 months, followed by the three-drug combinations, b) three received the three-drug combinations from the beginning, c) four received the four-drug combinations also from the beginning, two having less than 10 CD4/mm3 at initiation of treatment, and two having more than 10...Continue Reading

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Citations

Oct 12, 2012·Parasitology Research·Zubeyda Akin Polat, Gulderen Karakus
Dec 31, 1997·American Journal of Surgery·D E Weiland
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Jan 1, 1996·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G MathéP Pontiggia
Jan 28, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Lebwohl, R Canetta
Jun 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jingzhang FanZhenggang Bi
Jun 17, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Veena ShatrugnaN Balakrishna
Sep 16, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Faidon MagkosLabros S Sidossis
Sep 12, 2006·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·F MagkosL S Sidossis
Jul 16, 2020·Journal of Cellular and Molecular Medicine·Rawan HallalFrédéric Mazurier

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