AIE-active theranostic system: selective staining and killing of cancer cells

Chemical Science
Chen GuiBen Zhong Tang

Abstract

Cancer is the leading cause of death worldwide. With the advantages of low cost, high sensitivity and ease of accessibility, fluorescence imaging has been widely used for cancer detection in the scientific field. Aggregation-induced emission luminogens (AIEgens) are a class of synthesized fluorescent probes with high brightness and photostability in the aggregate state. Herein, a new positively-charged AIEgen, abbreviated as TPE-IQ-2O, is designed and characterized. TPE-IQ-2O not only can distinguish cancer cells from normal cells with high contrast with the aid of the difference in mitochondrial membrane potential as well as the quantity of mitochondria, but it also works as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species upon white light irradiation, thus making it a promising AIE theranostic system.

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Citations

Sep 15, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Yang KangLin-Pei Jin
Jul 16, 2019·Biomaterials Science·Feng YinBen Zhong Tang
Jun 30, 2019·Chemistry, an Asian Journal·Seong-Hyun ParkInjae Shin
Aug 1, 2020·Advanced Materials·Haoke ZhangBen Zhong Tang
Sep 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ming-Yu WuShun Feng
Oct 13, 2018·Chemical Science·Yuan GuBen Zhong Tang
Sep 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Junho AhnJong Hwa Jung
May 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meijuan JiangBen Zhong Tang
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhensheng LiZhigang Xie
May 17, 2018·Chemistry : a European Journal·Ruibing AnHong Liu
Jul 31, 2019·Chemical Science·Peng GaoBo Tang
Aug 25, 2017·Chemical Communications : Chem Comm·Zhenglin ZhangOgnjen Š Miljanić
Dec 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fujie JiaFeng Li
May 21, 2020·Angewandte Chemie·Dingyuan YanBen Zhong Tang
Feb 16, 2021·Journal of Drug Targeting·Rashmi Kumari, Dhanya Sunil
Apr 21, 2021·ACS Applied Materials & Interfaces·Peilin GuJianlei Shen
Apr 27, 2021·ACS Applied Materials & Interfaces·Rui WangJuyoung Yoon
May 13, 2021·Chemical Communications : Chem Comm·Jun LiJishan Li
May 28, 2021·Chemical Science·Shanshan LiuBin Liu
Sep 28, 2018·Inorganic Chemistry·Moustafa T Gabr, F Christopher Pigge
Nov 16, 2017·ACS Applied Materials & Interfaces·Ju MeiHe Tian
May 29, 2019·ACS Applied Materials & Interfaces·Peng GaoBo Tang

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Methods Mentioned

BETA
fluorescence imaging
NMR
fluorescence microscopy
flow cytometry
imaging techniques
Assay
column chromatography

Software Mentioned

ZEN
Theranostics
MATLAB

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