AII amacrine cells express functional NMDA receptors

Neuroreport
E Hartveit, M L Veruki

Abstract

NMDA and non-NMDA receptors mediate the majority of fast excitatory synaptic transmission in the CNS. AII amacrine cells in the mammalian retina receive glutamatergic input from rod bipolar cells and are known to express non-NMDA receptors. We have investigated the expression of NMDA receptors in these cells by recording responses to exogenously applied NMDA in whole-cell recordings in slices of rat retina. Most cells displayed clear responses to NMDA. The responses could be blocked by a specific NMDA receptor antagonist and were characterized by voltage-dependent block with outward rectification. These results suggest that NMDA receptors could play a role in mediating excitatory synaptic input to AII amacrine cells.

References

Nov 8, 1992·The Journal of Comparative Neurology·E StrettoiR F Dacheux
Jun 22, 1991·Proceedings. Biological Sciences·M Farrant, S G Cull-Candy
Apr 1, 1991·Physiological Reviews·H Wässle, B B Boycott
Jul 17, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V H Perry, M Walker
Jul 1, 1994·Physiological Reviews·C J McBain, M L Mayer

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Citations

Oct 26, 1999·Progress in Retinal and Eye Research·W B Thoreson, P Witkovsky
Apr 7, 2006·Visual Neuroscience·Olivia N DumitrescuHeinz Wässle
Sep 15, 2010·The Journal of General Physiology·Haruhisa OkawaAlapakkam P Sampath
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrés E Chávez, Jeffrey S Diamond
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin H TrotterJoachim Herz
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Wade KothmannJohn O'Brien
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·W Wade KothmannJohn O'Brien
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrés E ChávezJeffrey S Diamond
Dec 14, 1999·The European Journal of Neuroscience·Y ShenX L Yang
Apr 3, 2001·The Journal of Comparative Neurology·R G PourchoD J Goebel
Apr 19, 2003·The Journal of Physiology·Margaret Lin VerukiEspen Hartveit
Mar 16, 2000·The Journal of Physiology·S A Bloomfield, D Xin
Feb 20, 2016·Neurology. Neuroimmunology and Neuroinflammation·Alexander U BrandtCarsten Finke
Sep 30, 2003·The Journal of Comparative Neurology·Ulrike GrünertPaul R Martin
Jul 11, 2012·Brain Research·Espen Hartveit, Margaret Lin Veruki
Dec 6, 2011·Experimental Eye Research·Clairton F de SouzaMonica L Acosta
Dec 24, 2005·The Journal of Comparative Neurology·Daniel Sun, Michael Kalloniatis
Jul 28, 2004·Molecular and Cellular Neurosciences·E M UllianB A Barres
Jul 9, 2013·Neuron·Alejandro Akrouh, Daniel Kerschensteiner
Oct 16, 2001·Journal of Neurophysiology·M J FrechK H Backus
Sep 25, 2017·Brain Structure & Function·Espen HartveitMargaret Lin Veruki

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