Ailanthus altissima (Miller) Swingle fruit - new acyl β-sitosteryl glucoside and in vitro pharmacological evaluation

Natural Product Research
Sohail KhanMuhammad Imran

Abstract

β-Sitosterol-3-O-(6'-O-13"-octadecenoyl)-β-D-glucoside (1), a new acyl β-sitosteryl glucoside, along with three known compounds β-sitosterol-3-O-β-D-glucoside (2), β-sitosterol (3) and methyl gallate (4) have been isolated from the ethyl acetate soluble fraction of methanolic extract of Ailanthus altissima fruits. Their structures were elucidated through spectroscopic data including 2D NMR, ESI-MS, methanolysis and oxidative cleavage of double bond. Antibacterial, antifungal, cytotoxic, phytotoxic and insecticidal activities were evaluated of compound 1, crude extract and its fractions so far for the first time. Pharmacological activities results showed that n-butanol fraction was good active against Pseudomonas aeruginosa and Salmonella typhi bacteria, and moderate active against Microsporum canis fungus. Crude extract, n-butanol and aqueous fractions showed good cytotoxicity. Moreover, compound 1, extract and all fractions showed notable phytotoxicity at higher concentrations, whereas all inactive against assayed insects.

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Citations

Feb 13, 2018·Natural Product Research·Jian-Cheng NiQi-Jian Chen
Feb 7, 2020·Journal of Asian Natural Products Research·Ye-Qing DuShao-Jiang Song
Aug 22, 2020·Journal of Asian Natural Products Research·Tian-Ming LvShao-Jiang Song

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Methods Mentioned

BETA
NMR

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