AIM2 is a potential therapeutic target in human renal carcinoma and suppresses its invasion and metastasis via enhancing autophagy induction

Experimental Cell Research
Dafei ChaiJunnian Zheng

Abstract

Absent in melanoma 2 (AIM2) as a tumor suppressor is recently recognized to play an important role in many human solid tumors. However, the biological significance and function of AIM2 in renal cell carcinoma (RCC) remain unknown. In this study, we proposed to investigate the clinicopathological and prognostic significance of AIM2 in RCC patient specimens, to analyze the correlation between AIM2 expression and disease progression, and to further investigate the role and mechanism of AIM2 in malignant behaviors of renal carcinoma by cellular and animal models. The correlation analysis showed that low AIM2 expression was significantly correlated with lymph node metastasis, poor 5-year overall (P < 0.05) and disease-specific survival (P < 0.05) in RCC patients. Over-expression of AIM2 in 786-O or OSRC-2 cells suppressed the cell proliferation, migration and invasion as compared with control. The increased AIM2 expression enhanced the expression of autophagy-related genes (Bcl-2, Beclin-1, LC3-Ⅱ, and ATG-5) and increased the ratio of LC3-Ⅱ/LC3-Ⅰin renal carcinoma cells. Of note, the blockade of autophagy by 3-Methyladenine (3-MA) abrogated the inhibition of cell migration and invasion by over-expressing AIM2, indicated that AIM2 su...Continue Reading

Citations

Oct 24, 2019·Annual Review of Physiology·Mary E Choi
Apr 7, 2019·Journal of Cellular Physiology·Minda ZhangRong Hu
Mar 2, 2021·Frontiers in Pharmacology·Ying-Hua He, Guo Tian
Mar 23, 2021·Biochimie·Xiaoli JuQiang Wang
Dec 28, 2018·Biochemical and Biophysical Research Communications·Yuri NakamuraKazuhiro Morishita
Apr 13, 2021·Frontiers in Cell and Developmental Biology·Shailendra ShahMing Zhong
May 21, 2021·Immunity, Inflammation and Disease·Huan ZhuHaijing Wu

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