Abstract
Absent in melanoma 2 (AIM2) as a tumor suppressor is recently recognized to play an important role in many human solid tumors. However, the biological significance and function of AIM2 in renal cell carcinoma (RCC) remain unknown. In this study, we proposed to investigate the clinicopathological and prognostic significance of AIM2 in RCC patient specimens, to analyze the correlation between AIM2 expression and disease progression, and to further investigate the role and mechanism of AIM2 in malignant behaviors of renal carcinoma by cellular and animal models. The correlation analysis showed that low AIM2 expression was significantly correlated with lymph node metastasis, poor 5-year overall (P < 0.05) and disease-specific survival (P < 0.05) in RCC patients. Over-expression of AIM2 in 786-O or OSRC-2 cells suppressed the cell proliferation, migration and invasion as compared with control. The increased AIM2 expression enhanced the expression of autophagy-related genes (Bcl-2, Beclin-1, LC3-Ⅱ, and ATG-5) and increased the ratio of LC3-Ⅱ/LC3-Ⅰin renal carcinoma cells. Of note, the blockade of autophagy by 3-Methyladenine (3-MA) abrogated the inhibition of cell migration and invasion by over-expressing AIM2, indicated that AIM2 su...Continue Reading
Citations
Mar 16, 2019·Phytotherapy Research : PTR·Xinli ShiSheng Li
Jun 19, 2019·Journal of Cellular Biochemistry·Yunjia YangRong Hu
Oct 24, 2019·Annual Review of Physiology·Mary E Choi
Jul 30, 2020·Journal of Cellular and Molecular Medicine·Dafei ChaiJunnian Zheng
Jul 3, 2020·Aging·Hui-Yu LinYuan-Feng Lin
Apr 7, 2019·Journal of Cellular Physiology·Minda ZhangRong Hu
Jun 22, 2020·Human Cell·Rui ZhouHonggang Yu
Sep 8, 2019·Cancers·Man WangKun Wang
Jan 26, 2021·Translational Oncology·Dafei ChaiJunnian Zheng
Oct 30, 2020·OncoTargets and Therapy·Xiang ZhuXiaojie Xu
Mar 2, 2021·Frontiers in Pharmacology·Ying-Hua He, Guo Tian
Mar 23, 2021·Biochimie·Xiaoli JuQiang Wang
Dec 28, 2018·Biochemical and Biophysical Research Communications·Yuri NakamuraKazuhiro Morishita
Apr 13, 2021·Frontiers in Cell and Developmental Biology·Shailendra ShahMing Zhong
May 21, 2021·Immunity, Inflammation and Disease·Huan ZhuHaijing Wu
Nov 7, 2021·Journal of Neuroinflammation·Rongjiao ShaoDerong Cui
Dec 23, 2021·Clinical Science·Yong WuMinmin Zhang
Dec 17, 2021·Molecular Medicine Reports·Jianping ZhengXiangxin Wang