AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.

Cell Death and Differentiation
R PieriniT Henry

Abstract

The inflammasome is a signalling platform leading to caspase-1 activation. Caspase-1 causes pyroptosis, a necrotic-like cell death. AIM2 is an inflammasome sensor for cytosolic DNA. The adaptor molecule ASC mediates AIM2-dependent caspase-1 activation. To date, no function besides caspase-1 activation has been ascribed to the AIM2/ASC complex. Here, by comparing the effect of gene inactivation at different levels of the inflammasome pathway, we uncovered a novel cell death pathway activated in an AIM2/ASC-dependent manner. Francisella tularensis, the agent of tularaemia, triggers AIM2/ASC-dependent caspase-3-mediated apoptosis in caspase-1-deficient macrophages. We further show that AIM2 engagement leads to ASC-dependent, caspase-1-independent activation of caspase-8 and caspase-9 and that caspase-1-independent death is reverted upon caspase-8 inhibition. Caspase-8 interacts with ASC and active caspase-8 specifically colocalizes with the AIM2/ASC speck thus identifying the AIM2/ASC complex as a novel caspase-8 activation platform. Furthermore, we demonstrate that caspase-1-independent apoptosis requires the activation of caspase-9 and of the intrinsic pathway in a typical type II cell manner. Finally, we identify the AIM2/ASC-d...Continue Reading

References

Jul 6, 2000·The EMBO Journal·A O AliprantisA Zychlinsky
Oct 4, 2000·The Journal of Experimental Medicine·V JesenbergerM Baccarini
Mar 21, 2003·Biochemical and Biophysical Research Communications·Junya MasumotoNaohiro Inohara
Jul 30, 2003·The Journal of Cell Biology·Michael KalaiPeter Vandenabeele
Jan 20, 2004·Nature Cell Biology·Takao OhtsukaSam W Lee
Sep 11, 2004·Journal of Medical Microbiology·Helena LindgrenAnders Sjöstedt
Feb 11, 2005·The Journal of Biological Chemistry·Mizuho HasegawaTakashi Suda
Oct 19, 2005·The Journal of Experimental Medicine·Sanjeev MariathasanDenise M Monack
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Apr 17, 2007·Annals of the New York Academy of Sciences·Paul KeimDavid M Wagner
Apr 25, 2007·The Journal of Experimental Medicine·Thomas HenryDenise M Monack
Jan 17, 2009·Nature Reviews. Microbiology·Tessa BergsbakenBrad T Cookson
Jan 23, 2009·Nature·Teresa Fernandes-AlnemriEmad S Alnemri
Jan 23, 2009·Nature Immunology·Tilmann BürckstümmerGiulio Superti-Furga
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mizuho HasegawaTakashi Suda
Jun 23, 2009·Seminars in Immunology·Igor E Brodsky, Denise Monack
Mar 4, 2010·Cellular and Molecular Life Sciences : CMLS·Franky Van HerreweghePeter Vandenabeele
Mar 31, 2010·Nature Immunology·Vijay A K RathinamKatherine A Fitzgerald
Mar 31, 2010·Nature Immunology·Teresa Fernandes-AlnemriEmad S Alnemri
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan W JonesDenise M Monack
Feb 8, 2011·Biochimica Et Biophysica Acta·Chahrazade Kantari, Henning Walczak
Mar 4, 2011·Nature·William J KaiserEdward S Mocarski
Oct 18, 2011·Nature·Nobuhiko KayagakiVishva M Dixit

❮ Previous
Next ❯

Citations

May 7, 2013·Cell Death and Differentiation·V SagulenkoK J Stacey
Jul 9, 2013·Cell Death and Differentiation·D L Vaux
Jul 17, 2012·Nature Chemical Biology·Aaron W PuriMatthew Bogyo
May 15, 2013·Nature Reviews. Rheumatology·Alexander SoNathalie Busso
Mar 5, 2013·PloS One·Nrusingh P MohapatraJohn S Gunn
Sep 24, 2013·PloS One·Olivia S SakhonJoao H F Pedra
Oct 19, 2012·Future Microbiology·Elodie RamondAlain Charbit
Dec 18, 2013·Future Microbiology·Mary SpeirThomas Naderer
Mar 19, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xuan LiZiad Mallat
Nov 30, 2013·Cellular and Molecular Life Sciences : CMLS·Antero SalminenKai Kaarniranta
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Dan WengEgil Lien
Aug 26, 2014·Nature Reviews. Immunology·J Magarian Blander
Dec 3, 2015·European Journal of Immunology·Si Ming ManThirumala-Devi Kanneganti
Oct 17, 2012·Trends in Immunology·Ian G Rodrigue-Gervais, Maya Saleh
Dec 15, 2015·Nature Reviews. Immunology·Si Ming Man, Thirumala-Devi Kanneganti
Dec 29, 2015·Cellular and Molecular Life Sciences : CMLS·Nidhi Sharma, Sushmita Jha
Jan 9, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephanie E AdamczakRobert W Keane
Oct 16, 2015·Cell Host & Microbe·Sophia G Zebell, Xinnian Dong
Feb 4, 2014·Journal of Neurochemistry·Richa HanamsagarTammy Kielian
Feb 3, 2016·Cellular Microbiology·Seong H ChowThomas Naderer
Apr 7, 2016·Cellular and Molecular Life Sciences : CMLS·Nathalia M de VasconcelosMohamed Lamkanfi
Apr 17, 2015·Immunological Reviews·Si Ming Man, Thirumala-Devi Kanneganti
Apr 14, 2016·Cellular and Molecular Life Sciences : CMLS·James E Vince, John Silke
Sep 3, 2013·Biochimica Et Biophysica Acta·Kate E Lawlor, James E Vince
May 28, 2013·Current Opinion in Microbiology·Youssef AachouiKatryn J Stacey
Jun 6, 2015·Military Medical Research·Yong YangJie Fan
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Younghee KimJayakrishna Ambati
Mar 4, 2014·Current Opinion in Microbiology·Jon A Hagar, Edward A Miao
Jun 14, 2016·Nature Reviews. Immunology·Petr Broz, Vishva M Dixit
Jun 22, 2016·The Journal of Cell Biology·Deepika Sharma, Thirumala-Devi Kanneganti
Oct 19, 2016·Cell Death and Differentiation·S A ConosL M Lindqvist
Feb 1, 2017·Nature Reviews. Immunology·Ine JorgensenEdward A Miao
Mar 28, 2017·Scientific Reports·Si Ming ManThirumala-Devi Kanneganti
Jul 13, 2013·Nature Reviews. Immunology·Petr Broz, Denise M Monack

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2021 Meta ULC. All rights reserved