Aiming for the elimination of viral hepatitis in Australia, New Zealand, and the Pacific Islands and Territories: Where are we now and barriers to meeting World Health Organization targets by 2030

Journal of Gastroenterology and Hepatology
Jess HowellMargaret E Hellard

Abstract

Viral hepatitis affects more than 320 million people globally, leading to significant morbidity and mortality due to liver failure and hepatocellular carcinoma (HCC). More than 248 million people (3.2% globally) are chronically infected with hepatitis B virus (HBV), and an estimated 80 million people (1.1% globally) are chronically infected with hepatitis C virus (HCV). In 2015, more than 700 000 deaths were directly attributable to HBV, and nearly 500 000 deaths were attributable to HCV infection; 2-5% of HBV-infected people develop HCC per annum irrespective of the presence of cirrhosis, whereas 1-5% HCV-infected people with advanced fibrosis develop HCC per annum. The rapidly escalating global mortality related to HBV and HCV related viral hepatitis to be the 7th leading cause of death worldwide in 2013, from 10th leading cause in 1990. Australia, New Zealand, and Pacific Island Countries and Territories fall within the World Health Organization Western Pacific Region, which has a high prevalence of viral hepatitis and related morbidity, particularly HBV. Remarkably, in this region, HBV-related mortality is greater than for tuberculosis, HIV infection, and malaria combined. The region provides a unique contrast in viral hepa...Continue Reading

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Citations

Mar 19, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takashi NishimuraShuhei Nishiguchi
Oct 8, 2020·Cells·Yinzong XiaoJessica Howell
Sep 25, 2020·Journal of Hepatology·Jessica HowellMargaret Hellard
Dec 15, 2020·The Medical Journal of Australia·John S LubelNick Shackel
Feb 21, 2021·The Medical Journal of Australia·Jessica HowellJoshua S Davis
Feb 26, 2021·Internal Medicine Journal·John S LubelNichols A Shackel
Jul 31, 2021·World Journal of Gastroenterology : WJG·Fátima Higuera-de la TijeraLuis Servín-Abad
Oct 9, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jess HowellPaul Gow

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