AIMing towards improved antitumor efficacy

Bioorganic & Medicinal Chemistry Letters
Matthew J WeaverNicholas R Natale

Abstract

Using the structure-activity relationship emerging from previous Letter, and guided by pharmacokinetic properties, new AIMs have been prepared with both improved efficacy against human glioblastoma cells and cell permeability as determined by fluorescent confocal microscopy. We present our first unambiguous evidence for telomeric G4-forming oligonucleotide anisotropy by NMR resulting from direct interaction with AIMs, which is consistent with both our G4 melting studies by CD, and our working hypothesis. Finally, we show that AIMs induce apoptosis in SNB-19 cells.

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Citations

Dec 7, 2018·Current Medicinal Chemistry·Maria A ChiacchioLaura Legnani
Jan 2, 2019·International Journal of Molecular Sciences·Lavinia A CarabetArtem Cherkasov

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis