PMID: 9525750Apr 3, 1998Paper

Air-filled ultrasound contrast agents do not damage the cerebral microvasculature or brain tissue in rats

Investigative Radiology
K J HaggagA Torvik

Abstract

Air microemboli may damage the cerebral microvasculature. The aim of this study was to evaluate the safety of ultrasound contrast agents composed of air microspheres with regard to cerebral damage when administered into the arterial system (ie, when not filtered by the capillary system of the lungs). Three experimental methods were used in 75 rats after injection of either Albunex, Echovist, or Levovist into the left heart ventricle. The alkaline phosphatase (ALP) method to demonstrate small segmental brain capillary and arteriolar dilatations (SCADs), intravenous injections of Evans blue and fluorescence microscopy to detect increased vascular permeability (blood-brain barrier damage), and histologic examination of the brain to detect microinfarction. Intracardiac injections of saline, air, and corn oil were used as controls. Brain microinfarcts and SCADs formation of the brain microvasculature occurred only after control injections with corn oil. None of the brains from animals that received ultrasound contrast agent showed gross discoloration, as an indication of increased vascular permeability, with the Evans blue/fluorescence microscopy method. Definite leakage of Evans blue occurred only after large doses (150 microL) of ...Continue Reading

References

Sep 1, 1979·Stroke; a Journal of Cerebral Circulation·H Fritz, K A Hossmann
Feb 1, 1991·Stroke; a Journal of Cerebral Circulation·D RussellJ A Zivin
Aug 1, 1990·Journal of the American College of Cardiology·S B FeinsteinP M Shah
Oct 1, 1990·Annals of Neurology·D M MoodyD S Prough
Jan 1, 1990·Stroke; a Journal of Cerebral Circulation·S C HelpsD F Gorman
Sep 1, 1990·Stroke; a Journal of Cerebral Circulation·S C HelpsD F Gorman
May 1, 1986·Stroke; a Journal of Cerebral Circulation·K A SotaniemiT E Hokkanen
Mar 1, 1970·Journal of the Neurological Sciences·M W BrightmanT S Reese
Oct 1, 1980·Acta Neurologica Scandinavica·B B Johansson
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·T W Furlow
Sep 1, 1980·Acta Psychiatrica Scandinavica·D M Ndetei
Feb 1, 1995·Stroke; a Journal of Cerebral Circulation·S OtisR Boyajian
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·F RiesR Schlief
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·W PugsleyS Newman
Jul 1, 1993·Journal of the Neurological Sciences·V R ChallaB T Troost
May 1, 1993·Stroke; a Journal of Cerebral Circulation·U BogdahnW Hassel
Jan 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·D A StumpS P Newman
Nov 1, 1991·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·F RiesR Schlief
Sep 1, 1959·Neurology·J C LEE, J OLSZEWSKI

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Citations

Jan 22, 2005·European Radiology·Jarl A JakobsenUNKNOWN Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
Sep 10, 2003·The Annals of Thoracic Surgery·Christian LundDavid Russell
Dec 4, 2003·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Jan StygallMichael J Harrison
Jun 11, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K J HaggagB Muan
Mar 15, 2011·Journal of Cardiac Surgery·Krishanu Chaudhuri, Silvana F Marasco
Mar 12, 2005·Journal of the Neurological Sciences·David Russell, Nathan Bornstein
Sep 16, 2015·Nature Communications·Stuart IbsenSreekanth H Chalasani
Dec 10, 1999·Investigative Radiology·V M Runge
Feb 18, 2005·European Heart Journal·Christian LundDavid Russell
Apr 6, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Felix SchlachetzkiUlrich Bogdahn

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