'Air hunger' arising from increased PCO2 in mechanically ventilated quadriplegics

Respiration Physiology
Robert B BanzettR Brown

Abstract

A number of investigators have proposed that the sense of respiratory discomfort accompanying hypercapnia depends on respiratory mechanoreceptors which inform the sensory cortex of reflex increases in breathing. To test this hypothesis, we studied subjects whose respiratory muscles were paralyzed, and who were thus unable to increase breathing in response to hypercapnia. We gradually elevated inspired PCO2 in four tracheostomized quadriplegic subjects supported by constant mechanical ventilation. These subjects reported sensations of 'air hunger' (e.g., "short of breath", "air-starved") when end-tidal PCO2 increased 10 Torr (mean) above their resting levels. In a second experiment we used the forced-choice technique to determine the ability of three of these subjects to detect repeated changes of end-tidal PCO2. Two detected 7 Torr changes, the third detected 11 Torr changes. These data suggest that changes in breathing are not necessary to evoke the sense of 'air hunger'. We conclude that the likely mechanisms are (1) projection of chemoreceptor afferent traffic to the sensory cortex, and (2) projection of corollary discharge from brainstem respiratory centers to the sensory cortex.

Citations

May 1, 1995·Medical & Biological Engineering & Computing·Y OkuM D Altose
Jan 1, 1990·Lung·R M SchwartzsteinS E Weinberger
Oct 18, 2013·Intensive Care Medicine·Matthieu SchmidtAlexandre Demoule
Dec 15, 2010·Journal of Anesthesia·Takashi Nishino
Sep 10, 2008·Current Oncology Reports·Giovanni Elia, Jay Thomas
Oct 1, 1992·Respiration Physiology·H L ManningR B Banzett
Aug 1, 1993·Respiration Physiology·S A SheaR B Banzett
Apr 1, 1994·Respiration Physiology·H L ManningJ C Leiter
Jan 1, 1996·Respiration Physiology·R B BanzettS A Shea
Mar 1, 1996·Respiration Physiology·P A FlumeL E Mattison
Oct 29, 1997·Respiration Physiology·A Guz
Oct 29, 1998·Biological Psychology·S A SheaR B Banzett
Jun 28, 2000·Journal of Pain and Symptom Management·J P JanssensV Titelion
Apr 1, 1997·Journal of Pain and Symptom Management·C Ripamonti, E Bruera
Mar 1, 2003·Respiratory Physiology & Neurobiology·Robert W LansingRobert B Banzett
Dec 7, 1995·The New England Journal of Medicine·H L Manning, R M Schwartzstein
Mar 8, 2011·British Journal of Anaesthesia·T Nishino
Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·S C GandeviaD K McKenzie
Mar 1, 1997·Respirology : Official Journal of the Asian Pacific Society of Respirology·D Joffe, N Berend
Jan 1, 1992·Clinical Physiology·O Nisell
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Pierantonio LavenezianaDenis E O'Donnell
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·E Bloch-SalisburyR B Banzett
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·E L De VitoF Pessolano
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·T NishinoJ Sato
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R W LansingR B Banzett
Apr 3, 2001·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Feb 1, 1992·The American Review of Respiratory Disease·K Gleeson, C W Zwillich
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Danny J EckertR Doug McEvoy
Jul 23, 2011·American Journal of Respiratory and Critical Care Medicine·Robert B BanzettRichard M Schwartzstein
Feb 18, 2012·American Journal of Respiratory and Critical Care Medicine·Mark B ParshallUNKNOWN American Thoracic Society Committee on Dyspnea
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·M Diane LougheedDenis E O'Donnell
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Francesco Gigliotti
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Ernesto Crisafulli, Enrico M Clini
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Pierantonio Laveneziana
Oct 28, 2005·International Journal of Behavioral Medicine·S Rietveld, J F Brosschot
Jun 18, 2002·The Lancet Oncology·Jay R Thomas, Charles F von Gunten
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M LiottiD Denton
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·S BrannanP T Fox
Sep 30, 2014·Respiratory Physiology & Neurobiology·Andrew P BinksRobert B Banzett

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