AIR inhaled insulin versus subcutaneous insulin: pharmacokinetics, glucodynamics, and pulmonary function in asthma

Diabetes Care
Michael WolztD B Muchmore

Abstract

This study evaluated pharmacokinetic and glucodynamic responses to AIR inhaled insulin relative to subcutaneous insulin lispro, safety, pulmonary function, and effects of salbutamol coadministration. Healthy, mildly asthmatic, and moderately asthmatic subjects (n = 13/group, aged 19-58 years, nonsmoking, and nondiabetic) completed this phase I, open-label, randomized, crossover euglycemic clamp study. Subjects received 12 units equivalent AIR insulin or 12 units subcutaneous insulin lispro or salbutamol plus AIR insulin (moderate asthma group only) before the clamp. AIR insulin exposure was reduced 34 and 41% (both P < 0.01) in asthmatic subjects (area under the curve(0-t'), 24.0 and 21.1 nmol x min x l(-1) in mild and moderate asthma subjects, respectively) compared with healthy subjects (35.2 nmol x min x l(-1)), respectively. Glucodynamic (G) effects were similar in healthy and mildly asthmatic subjects (G(tot) = 38.7 and 23.4 g, respectively; P = 0.16) and were reduced in moderately asthmatic subjects (G(tot) = 10.7 g). Salbutamol pretreatment (moderately asthmatic subjects) improved bioavailability. AIR insulin had no discernable effect on pulmonary function. AIR insulin adverse events (cough, headache, and dizziness) were...Continue Reading

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Citations

Mar 5, 2008·Nature Clinical Practice. Endocrinology & Metabolism·William J Jeffcoate
Sep 30, 2009·Diabetes Technology & Therapeutics·Amparo de la PeñaDouglas B Muchmore
Mar 18, 2010·Vascular Health and Risk Management·Lucy D Mastrandrea
Dec 25, 2010·Nanomedicine·Fernanda AndradeBruno Sarmento
Mar 14, 2013·Inhalation Toxicology·Mary C McElroyRon K Wolff
May 14, 2014·Advanced Drug Delivery Reviews·David CipollaAnthony Hickey
Oct 11, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F DepreterK Amighi
Mar 18, 2010·British Journal of Clinical Pharmacology·Astrid H PetersenThomas R Pieber
Nov 13, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Astrid A ReusC Frieke Kuper

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