Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms

Journal of the American College of Cardiology
Boris Z SimkhovichRobert A Kloner

Abstract

Recent epidemiologic studies show that increased levels of air pollutants are positively associated with cardiovascular morbidity and mortality. Inhalation of air pollutants affects heart rate, heart rate variability, blood pressure, vascular tone, blood coagulability, and the progression of atherosclerosis. Several categories within the general population (i.e., people with pre-existing cardiovascular disease and diabetic and elderly individuals) are considered to be more susceptible to air pollution-mediated cardiovascular effects. Major mechanisms of inhalation-mediated cardiovascular toxicity include activation of pro-inflammatory pathways and generation of reactive oxygen species. Although most studies focus on the influence of systemic effects, recent studies indicate that ultrafine particles may be translocated into the circulation and directly transported to the vasculature and heart where they can induce cardiac arrhythmias and decrease cardiac contractility and coronary flow.

References

May 1, 1992·Archives of Environmental Health·C A PopeM R Ransom
Nov 1, 1989·Archives of Environmental Health·M T KleinmanJ L Whittenberger
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·C A PopeC W Heath
Jan 1, 1994·Annual Review of Public Health·D W Dockery, C A Pope
Dec 9, 1993·The New England Journal of Medicine·D W DockeryF E Speizer
Jan 1, 1994·Environmental Research·J Schwartz
Jan 1, 1994·Environmental Research·J Schwartz
Nov 1, 1993·European Heart Journal·J McMurrayH J Dargie
Aug 1, 1997·Occupational and Environmental Medicine·J D PolonieckiH R Anderson
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine· Pope CA3rdJ Schwartz
Oct 28, 1999·American Heart Journal·C A PopeD W Dockery
Mar 22, 2000·Circulation·D R GoldR Verrier
May 17, 2000·The Science of the Total Environment·R M Harrison, J Yin
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·A J GhioR B Devlin
Dec 5, 2000·Environmental Health Perspectives·A ZanobettiD W Dockery
Dec 15, 2000·The New England Journal of Medicine·J M SametS L Zeger
Mar 15, 2001·Lancet·B NemeryA Nemmar
Apr 9, 2001·American Journal of Public Health·W H HelfandP Theerman
Apr 9, 2001·American Journal of Public Health·A Ibald-MulliA Peters
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·A J Ghio, R B Devlin
Mar 7, 2002·JAMA : the Journal of the American Medical Association·C Arden PopeGeorge D Thurston
Mar 19, 2002·Journal of the American College of Cardiology·Tatsushi SuwaStephan F van Eeden
Aug 23, 2002·Epidemiology·Antonella Zanobetti, Joel Schwartz
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Matthew J CampenWilliam P Watkinson
Dec 28, 2002·Environmental Health Perspectives·Devra L DavisTony Fletcher

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Citations

Aug 9, 2011·Basic Research in Cardiology·Lucas AndréOlivier Cazorla
Aug 21, 2009·Journal of Thrombosis and Thrombolysis·Shepard D Weiner, LeRoy E Rabbani
Jan 18, 2011·Sleep & Breathing = Schlaf & Atmung·David KristoPatrick Strollo
Jun 27, 2012·Sleep & Breathing = Schlaf & Atmung·Maha K Abou-Khadra
May 3, 2013·Environmental Science and Pollution Research International·G Smilin Bell AseervathamD Arul Ananth
Jul 6, 2010·Cardiovascular Toxicology·Haiyan TongRobert B Devlin
Sep 18, 2013·Annales de cardiologie et d'angéiologie·V K MassambaA Levêque
Mar 12, 2010·Cardiology in the Young·Arcangelo IannuzziMario Polverino
Feb 22, 2013·Environmental Science. Processes & Impacts·Helena NilssonHåkan Westberg
Aug 24, 2010·American Journal of Epidemiology·Robert A SilvermanDavid J Prezant
Sep 15, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mehdi S HazariAimen K Farraj
Jul 3, 2010·Journal of Occupational and Environmental Medicine·Helen H Suh, Antonella Zanobetti
Sep 4, 2013·Journal of Epidemiology and Community Health·Ana Fernández-Somoano, Adonina Tardon
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Maria K SchwartzVirginia M Miller
Jun 30, 2010·Circulation·Qinghua SunLoren E Wold
Mar 27, 2010·Stroke; a Journal of Cerebral Circulation·Jiu-Chiuan Chen
Dec 19, 2009·American Journal of Respiratory and Critical Care Medicine·Lucas AndreSylvain Richard
Sep 4, 2010·American Journal of Respiratory Cell and Molecular Biology·Jie ChaoNorberto C Gonzalez
Jun 24, 2009·Respiratory Research·Jie ChaoNorberto C Gonzalez
May 9, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kayo UedaMasaji Ono
Feb 4, 2010·Environmental Health Perspectives·Lotte JacobsTim S Nawrot
Feb 18, 2010·PloS One·Nino KünzliWendy J Mack
Jul 10, 2010·International Journal of Environmental Research and Public Health·Aleck OstryDiana M Allen
Oct 20, 2011·Hämostaseologie·J Emmerechts, M F Hoylaerts
Feb 5, 2013·Journal of Environmental Management·Terence J Centner, Gregory Colson
Jan 5, 2016·Journal of the Air & Waste Management Association·Xi ChenShengji Luan
Jun 23, 2009·The Science of the Total Environment·Brian J MajesticPierre Herckes
Nov 5, 2011·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Cox
Oct 25, 2013·Bulletin of Environmental Contamination and Toxicology·Faruq Mohammad, Tanvir Arfin
Jan 13, 2015·Journal of Environmental and Public Health·Anders C Erickson, Laura Arbour
Aug 3, 2013·Inhalation Toxicology·Ta-Liang ChenTzuu-Huei Ueng

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