Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Environmental Science & Technology
Kathrin Reinmuth-SelzleUlrich Pöschl

Abstract

Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immu...Continue Reading

References

Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Nov 15, 1985·Archives of Biochemistry and Biophysics·W A PrützE J Land
Nov 1, 1969·Atmospheric Environment·J B MuddT T McManus
Feb 1, 1983·The Journal of Allergy and Clinical Immunology·J W LarrickD Levy
Feb 1, 1995·Free Radical Biology & Medicine·S J Stohs, D Bagchi
Dec 9, 1993·The New England Journal of Medicine·D W DockeryF E Speizer
Apr 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R B SporikT A Platts-Mills
Jul 1, 1996·Chemical Research in Toxicology·J S Beckman
Dec 6, 1997·The Journal of Allergy and Clinical Immunology·G F SchäppiR B Knox
Jan 14, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L Berrens, B de la Cuadra López
Mar 26, 1998·Biological & Pharmaceutical Bulletin·H KanemitsuY Mori
Sep 16, 1998·American Journal of Public Health·J HeinrichH E Wichmann
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J U AhlholmJ Savolainen
May 8, 1999·Biophysical Journal·W S HlavacekR G Posner
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·D Diaz-SanchezA Saxon
Jun 1, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·R D HubyI Kimber
Aug 2, 2000·Allergy·U Wahn
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T S HiuraA E Nel
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·N E AvissarJ N Finkelstein
Feb 22, 2001·Free Radical Biology & Medicine·R RadiA Cayota
Jul 13, 2001·The Journal of Allergy and Clinical Immunology·D P Skoner
Oct 26, 2001·Current Opinion in Immunology·J RingH Behrendt
Jan 5, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J RingH Behrendt
Jan 10, 2002·Nature·Paul J Crutzen
Jan 19, 2002·The Journal of Allergy and Clinical Immunology·Philip E TaylorM Michael Glovsky
Feb 9, 2002·Environmental Health Perspectives·Robert J PandyaJohn R Balmes
Mar 6, 2002·The Journal of Clinical Investigation·Michael R Knowles, Richard C Boucher
Apr 3, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Peter WaynePaul Epstein
Apr 16, 2002·The Journal of Biological Chemistry·Jesper E MogensenDaniel E Otzen
May 8, 2002·The Journal of Allergy and Clinical Immunology·Claudia Traidl-HoffmannHeidrun Behrendt
May 8, 2002·The Journal of Allergy and Clinical Immunology·Gilles DevouassouxDavid Diaz-Sanchez
Jun 4, 2002·Nature Medicine·Markus F NeurathLaurie H Glimcher
Jun 6, 2002·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Paul J Crutzen
Sep 10, 2002·Molecular Immunology·Richard G PosnerWilliam S Hlavacek
Sep 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H BayramM M Abdelaziz

❮ Previous
Next ❯

Citations

Apr 27, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D CaillaudM Thibaudon
Nov 26, 2018·The Clinical Respiratory Journal·Mohammad Reza FazlollahiMostafa Moin
Feb 26, 2019·Basic & Clinical Pharmacology & Toxicology·Ieva KulvinskieneRuta Aldonyte
Nov 17, 2017·Nature·Jos Lelieveld, Ulrich Pöschl
Jul 28, 2020·Expert Review of Respiratory Medicine·Alicia V GayleElaine I Fuertes
Jun 27, 2019·Nature·Xiangdong LiHaidong Kan
Sep 5, 2020·Clinical and Translational Allergy·Lisa PointnerLorenz Aglas
Jun 7, 2019·Allergy, Asthma & Immunology Research·Nathalie AcevedoLuis Caraballo
Jul 15, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Regina PickfordAlexandra Schneider
Aug 14, 2020·Environmental Science and Pollution Research International·Maria Pilar PlazaCarmen Galán
Jun 20, 2020·Clinical and Translational Allergy·Claudia AlessandriAdriano Mari
Dec 24, 2018·Allergologia et immunopathologia·A ArmentiaD Fernandez
Feb 8, 2021·The Science of the Total Environment·Carlos Blanco-AlegreRoberto Fraile
Feb 20, 2020·Environmental Research·Penelope J JonesFay H Johnston
Nov 24, 2020·Frontiers in Cellular and Infection Microbiology·Claudia GrehnCarsten Schwarz
Dec 15, 2020·The Science of the Total Environment·Holly C Y LamElaine Fuertes
May 12, 2019·Environmental Research·Jesús RojoJeroen Buters
Jun 11, 2021·Frontiers in Microbiology·Asma ImranMuhammad Ahmad
Jun 16, 2021·Critical Reviews in Food Science and Nutrition·Hanieh MalmirAhmad Esmaillzadeh
Jun 20, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Rosa CodinaRichard F Lockey
Jul 28, 2021·Primary Care·Arezoo RajaeeKatherine M Pohlgeers
Nov 8, 2017·Environmental Science & Technology·Manabu ShiraiwaKei Sato
Sep 25, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Wenjing ZhuYuzhi Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
chemical modification

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.