Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immu...Continue Reading
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
Reactions of nitrogen dioxide in aqueous model systems: oxidation of tyrosine units in peptides and proteins
Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production
Concentrations of the major birch tree allergen Bet v 1 in pollen and respirable fine particles in the atmosphere
The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro
Genetic and environmental factors affecting the allergenicity of birch (Betula pubescens ssp. czerepanovii [Orl.] Hämet-ahti) pollen
Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa
Airway diseases and allergies in East and West German children during the first 5 years after reunification: time trends and the impact of sulphur dioxide and total suspended particles
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite. Implications for tyrosine modification by nitric oxide/superoxide in vivo
The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles
Nitration and hydroxylation of aromatic amino acid and guanine by the air pollutant peroxyacetyl nitrate
Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung
Localization, release and bioavailability of pollen allergens: the influence of environmental factors
Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction
Production of allergenic pollen by ragweed (Ambrosia artemisiifolia L.) is increased in CO2-enriched atmospheres
Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytes
Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils
Suppression of autologous peripheral blood mononuclear cell proliferation by alveolar macrophages from young infants
The effects of industrial and agricultural practices on atmospheric chemistry and climate during the anthropocene
Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation
Effect of ozone and nitrogen dioxide on the permeability of bronchial epithelial cell cultures of non-asthmatic and asthmatic subjects
Lab on a tip: atomic force microscopy - photothermal infrared spectroscopy of atmospherically relevant organic/inorganic aerosol particles in the nanometer to micrometer size range
Short-term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France
The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma.
Climate change, air pollution, and allergic respiratory diseases: a call to action for health professionals.
Development of a sandwich ELISA with potential for selective quantification of human lactoferrin protein nitrated through disease or environmental exposure
Bibliometric analysis of peer-reviewed literature on climate change and human health with an emphasis on infectious diseases.
Atmospheric protein chemistry influenced by anthropogenic air pollutants: nitration and oligomerization upon exposure to ozone and nitrogen dioxide
Socheongryong-tang for improving nasal symptoms associated with allergic rhinitis: A study protocol for a randomized, open-label, cetirizine controlled, clinical trial
[Combined effects of different environmental factors on health: air pollution, temperature, green spaces, pollen, and noise].
Atmospheric pollutants and their association with olive and grass aeroallergen concentrations in Córdoba (Spain).
Nitration of Wheat Amylase Trypsin Inhibitors Increases Their Innate and Adaptive Immunostimulatory Potential in vitro
Spatio-temporal assessment of ambient air quality, their health effects and improvement during COVID-19 lockdown in one of the most polluted cities of India.
Search for New Allergens in Lolium perenne Pollen Growing under Different Air Pollution Conditions by Comparative Transcriptome Study
Chemical and isotopic characteristics of PM2.5 over New Delhi from September 2014 to May 2015: Evidences for synergy between air-pollution and meteorological changes.
Changes in ambient temperature increase hospital outpatient visits for allergic rhinitis in Xinxiang, China.
Effects of high temperature on existing allergic symptoms and the effect modification of allergic history on health outcomes during hot days among adults: An exploratory cross-sectional telephone survey study
The need for Pan-European automatic pollen and fungal spore monitoring: A stakeholder workshop position paper.
Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-κB: Implications for the health effects of air pollution and oxidative stress.
Influence of environmental drivers on allergy to pollen grains in a case study in Spain (Madrid): meteorological factors, pollutants, and airborne concentration of aeroallergens.
The Consequences of Our Changing Environment on Life Threatening and Debilitating Fungal Diseases in Humans.
Characterising non-linear associations between airborne pollen counts and respiratory symptoms from the AirRater smartphone app in Tasmania, Australia: A case time series approach.
Fish consumption during pregnancy and risk of allergic diseases in the offspring: A systematic review and meta-analysis.
Oligomerization and Nitration of the Grass Pollen Allergen Phl p 5 by Ozone, Nitrogen Dioxide, and Peroxynitrite: Reaction Products, Kinetics, and Health Effects.
Short term physician visits and medication prescriptions for allergic disease associated with seasonal tree, grass, and weed pollen exposure across the United States.
Occurrence of Aerosol Proteinaceous Matter in Urban Beijing: An Investigation on Composition, Sources, and Atmospheric Processes During the "APEC Blue" Period
Contributions of City-Specific Fine Particulate Matter (PM2.5 ) to Differential In Vitro Oxidative Stress and Toxicity Implications between Beijing and Guangzhou of China
Proteins and Amino Acids in Fine Particulate Matter in Rural Guangzhou, Southern China: Seasonal Cycles, Sources, and Atmospheric Processes
Atypical asthma in children who present with isolated chest tightness: risk factors and clinical features.
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
Allergies & Environmental Factors
Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.