Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children

Environmental Research
Claudia KlümperGINIplus and LISAplus Study Groups

Abstract

Epidemiological studies indicate that asthmatic children are more susceptible to traffic-related air pollution exposure than non-asthmatic children. Local and systemic inflammation in combination with oxidative stress have been suggested as a possible susceptibility factor. We investigated effect modification by asthma status for the association between air pollution exposure and systemic effects using whole blood cytokine responsiveness as an inflammatory marker. The study was nested within the two German birth cohort studies GINIplus and LISAplus and initially designed as a random sub-sample enriched with asthmatic children. Using data from 27 asthmatic and 59 non-asthmatic six-year-old children we measured the production of Interleukin-6 (IL)-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in whole blood after ex-vivo stimulation with urban particulate matter (EHC-93). Air pollution exposure (nitrogen dioxide (NO2), nitrogen oxides (NOx), particulate matter with an aerodynamic diameter <10μm (PM10), particulate matter with an aerodynamic diameter <2.5μm (PM2.5mass), coarse particulate matter (PMcoarse) and PM2.5absorbance (PM2.5abs)) was modell...Continue Reading

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Citations

Apr 23, 2016·Pediatric Pulmonology·David J BirnkrantTerry L Noah
Oct 30, 2016·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Sergio Manzetti, Otto Andersen
Jul 4, 2017·Environmental Health Perspectives·Olena GruzievaGöran Pershagen
Jul 29, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Florence Chau-EtchepareMichael Schivo
May 10, 2017·Journal of Occupational and Environmental Medicine·Eunice Y LeeJohn R Balmes
Jul 6, 2020·Environmental Health : a Global Access Science Source·Linsey E S de GrootRené Lutter
May 4, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Claudia Traidl-Hoffmann

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