Air pollution and molecular changes in age-related diseases.

International Journal of Environmental Health Research
B HermanovaR J Sram

Abstract

Assessment of the impact that air contaminants have on health is difficult as this is a complex mixture of substances that varies depending on the time and place. There are many studies on the association between air pollution and increased morbidity and mortality. Before the effect of polluted air is manifested at the level of the organs, an impact can be observed at the molecular level. These include some new biomarkers, like a shortening of the mean telomere length in DNA, dysregulation of gene expression caused by microRNA levels or a variation in the copy number of mitochondrial DNA. These changes may predispose individuals to premature development of age-related diseases and consequently to shortening of life. The common attribute, shared by changes at the molecular level and the development of diseases, is the presence of oxidative stress.

References

Jun 20, 1992·Journal of Molecular Biology·M Z LevyC B Harley
Apr 18, 1991·Nature·E H Blackburn
Jul 13, 2002·Trends in Biochemical Sciences·Thomas von Zglinicki
Oct 24, 2003·The New England Journal of Medicine·Stefan BlankenbergUNKNOWN AtheroGene Investigators
Mar 31, 2004·Molecular Aspects of Medicine·Beatriz González-Flecha
Jun 3, 2004·Circulation·Robert D BrookUNKNOWN Expert Panel on Population and Prevention Science of the American Heart Association
Mar 16, 2005·Lancet·Anthony Seaton, Kenneth Donaldson
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Feb 8, 2006·International Journal of Cancer. Journal International Du Cancer·Paolo VineisElio Riboli
Jun 30, 2006·Journal of the Air & Waste Management Association·C Arden Pope, Douglas W Dockery
Jul 1, 2006·Genome Research·Jennifer L FreemanCharles Lee
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Nicholas L MillsDavid E Newby
Jan 12, 2010·Environmental Health Perspectives·Valentina BollatiAndrea Baccarelli
Jan 11, 2011·Environment International·Rebeca RamisGonzalo López-Abente
Jan 14, 2011·Environmental Health Perspectives·Ole Raaschou-NielsenAnne Tjønneland
Oct 19, 2011·Environmental Health Perspectives·Michele CarugnoAndrea Baccarelli
Jul 24, 2012·Advanced Drug Delivery Reviews·Dan Xu, Hidetoshi Tahara
Nov 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Thomas MontavonDenis Duboule
Dec 27, 2012·The World Allergy Organization Journal·Esra BirbenOmer Kalayci
Mar 28, 2013·Occupational and Environmental Medicine·Marie-Élise ParentAlexandre Liautaud
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Iain M CareyH Ross Anderson
Jul 19, 2013·BioMed Research International·Abderrahim NemmarErnesto Alfaro-Moreno
Nov 22, 2013·Epidemiology·Serena FossatiJoel Schwartz
Feb 25, 2014·International Journal of Hygiene and Environmental Health·A Izzotti, A Pulliero
May 2, 2014·Experimental and Molecular Pathology·Wenlin BaiAi Gao
Jul 10, 2014·BMJ : British Medical Journal·Philip C HaycockPeter Willeit
Jan 22, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Farkhondeh PouresmaeiliMaryam Kamarehei
Jan 24, 2015·Environmental Health Perspectives·Karen VrijensTim S Nawrot
Aug 15, 2015·Thoracic Cancer·Gongbo ChenXiaonong Zou
Oct 16, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kerryn W RedingDale P Sandler
Nov 17, 2015·International Journal of Molecular Sciences·Haiyan WeiYuepu Pu
Mar 5, 2016·Molecular Medicine Reports·Concettina FengaChiara Costa
Apr 23, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Maria TsamouTim S Nawrot
Jun 21, 2016·International Journal of Hygiene and Environmental Health·Antonin AmbrozRadim J Sram
Jul 1, 2016·Current Environmental Health Reports·Dries S Martens, Tim S Nawrot

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.