Air pollution and telomere length: a systematic review of 12,058 subjects

Cardiovascular Diagnosis and Therapy
Bing ZhaoKazuaki Negishi

Abstract

Over recent decades, adverse effects of ambient air pollution on the cardiovascular system have been clearly demonstrated. However, the underlying mechanisms are not fully elucidated. Air pollution may accelerates biological aging and thereby the susceptibility to cardiovascular diseases (CVDs). Telomeres are tandem repetitive DNA complexes that play a critical role in maintaining chromosome stability. There are, however, heterogeneities among the reported effects of air pollution on telomere. This study sought to evaluate the existing literature on the association between air pollution and telomere length (TL). Two reviewers independently searched on electronic databases including PUBMED, EMBASE, SCOPUS, WEB OF SCIENCE and Ovid. The key terms were "air pollution" and "telomere" without language restriction. Articles relating to tobacco smoke were excluded. A total of 12,058 subjects from 25 articles remained for final review. All were observational studies: 14 cross-sectional, 6 cohort and 5 case-control studies. Nineteen (76%) assessed leukocyte telomere length (LTL) of which 15 found associations between air pollution and shorter TL, 2 with longer TL, 1 had mixed results, and a study of patients with type 2 diabetes found no...Continue Reading

Citations

Nov 28, 2020·Biodemography and Social Biology·Belinda L NeedhamBhramar Mukherjee
Aug 9, 2020·Environmental Pollution·Mohammad MiriPayam Dadvand
Nov 30, 2020·The Lancet. Diabetes & Endocrinology·Feifei ChengRonald C W Ma
Jan 16, 2021·Journal of the American College of Cardiology·Panagiota Pietri, Christodoulos Stefanadis
Apr 27, 2020·Mechanisms of Ageing and Development·Agostino Di Ciaula, Piero Portincasa
Jan 30, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Agnes Maria LedererNandu Goswami
Jul 11, 2021·Mechanisms of Ageing and Development·Lucía Chico-SordoElisa Varela
Sep 17, 2021·Dermatologic Therapy·Katerina DamevskaStefana Damevska
Oct 17, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Qinglin SunJunchao Duan

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