Air pollution, ethnicity and telomere length in east London schoolchildren: An observational study.

Environment International
Robert T WaltonJonathan Grigg

Abstract

Short telomeres are associated with chronic disease and early mortality. Recent studies in adults suggest an association between telomere length and exposure to particulate matter, and that ethnicity may modify the relationship. However associations in children are unknown. We examined associations between air pollution and telomere length in an ethnically diverse group of children exposed to high levels of traffic derived pollutants, particularly diesel exhaust, and to environmental tobacco smoke. Oral DNA from 333 children (8-9years) participating in a study on air quality and respiratory health in 23 inner city London schools was analysed for relative telomere length using monochrome multiplex qPCR. Annual, weekly and daily exposures to nitrogen oxides and particulate matter were obtained from urban dispersion models (2008-10) and tobacco smoke by urinary cotinine. Ethnicity was assessed by self-report and continental ancestry by analysis of 28 random genomic markers. We used linear mixed effects models to examine associations with telomere length. Telomere length increased with increasing annual exposure to NOx (model coefficient 0.003, [0.001, 0.005], p<0.001), NO2 (0.009 [0.004, 0.015], p<0.001), PM2.5 (0.041, [0.020, 0.0...Continue Reading

References

Jul 1, 1989·The American Review of Respiratory Disease·F W HendersonN J Haley
Dec 22, 2004·Mechanisms of Ageing and Development·T von ZglinickiS P Jackson
Apr 9, 2005·The New England Journal of Medicine·Hiroki YamaguchiNeal S Young
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Sep 21, 2007·Human Molecular Genetics·Tim De MeyerUNKNOWN Asklepios investigators
Apr 9, 2008·Physiological Reviews·Geraldine Aubert, Peter M Lansdorp
Sep 19, 2008·The Lancet Oncology·Dean OrnishElizabeth H Blackburn
Dec 17, 2009·The New England Journal of Medicine·Rodrigo T Calado, Neal S Young
Feb 4, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Annette L FitzpatrickAbraham Aviv
Apr 7, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ingrid M WentzensenSharon A Savage
Feb 28, 2013·Journal of Exposure Science & Environmental Epidemiology·Sean D BeeversDavid C Carslaw
May 6, 2014·Experimental Gerontology·Johan SvenssonSofia Movérare-Skrtic
Jul 2, 2014·BMC Genomics·Jacobo Pardo-SecoAntonio Salas
Aug 12, 2014·Biochemical Society Transactions·Mark R Miller
Sep 19, 2014·Journal of the National Cancer Institute·Mark M IlesUNKNOWN GenoMEL Consortium
Dec 4, 2015·Proceedings. Biological Sciences·Thor Harald RingsbyPat Monaghan

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Citations

Oct 29, 2018·Environmental Science and Pollution Research International·Behnoush SaneiMohammad Javad Zare Sakhvidi
Dec 21, 2018·Critical Reviews in Toxicology·Peter MøllerMartin Roursgaard
Dec 15, 2017·European Journal of Clinical Nutrition·Peter L RippbergerJohn A Batsis
Jul 30, 2017·Environmental Health : a Global Access Science Source·Julie CarréRoger Léandri
Nov 28, 2018·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Joseph L ServadioNisha Botchwey
Jul 3, 2019·International Journal of Environmental Research and Public Health·Frans EversonHans Strijdom
Nov 28, 2020·Biodemography and Social Biology·Belinda L NeedhamBhramar Mukherjee
Nov 22, 2020·The Science of the Total Environment·Ruiying LiChongjian Wang

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