Air pollution exposure and risk of spontaneous abortion in the Nurses' Health Study II

Human Reproduction
Audrey J GaskinsShruthi Mahalingaiah

Abstract

Is there an association between air pollution exposures and the risk of spontaneous abortion (SAB)? Higher exposure to particulate matter (PM) air pollution above and beyond a woman's average exposure may be associated with greater risk of SAB, particularly among women experiencing at least one SAB during follow-up. There is sufficient biologic plausibility to suggest that air pollution adversely affects early pregnancy outcomes, particularly pregnancy loss; however, the evidence is limited. Our prospective cohort study included 19 309 women in the Nurses' Health Study II who contributed a total of 35 025 pregnancies between 1990 and 2008. We also conducted a case-crossover analysis among 3585 women (11 212 pregnancies) with at least one SAB and one live birth during follow-up. Proximity to major roadways and exposure to PM <10 microns (PM10), 2.5-10 microns (PM2.5-10) and <2.5 microns (PM2.5) were determined for residential addresses between 1989 and 2007. Pregnancy outcomes were self-reported biannually throughout follow-up and comprehensively in 2009. Multivariable log-binomial regression models with generalized estimating equations were used to estimate the risk ratios and 95% CIs of SAB. Conditional logistic regression was...Continue Reading

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Citations

Dec 11, 2020·Toxicology Letters·Eun-Jung ParkKwang Pyo Kim
Jun 12, 2021·Environment International·Audrey J GaskinsUNKNOWN EARTH Study Team
Aug 20, 2021·Ecotoxicology and Environmental Safety·Huiyu WangJiwei Li
Nov 23, 2021·Chemical Research in Toxicology·Reena BermanHong Wei Chu

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