Air Pollution Exposure During Pregnancy and Fetal Markers of Metabolic function: The MIREC Study

American Journal of Epidemiology
Eric LavigneWilliam D Fraser

Abstract

Previous evidence suggests that exposure to outdoor air pollution during pregnancy could alter fetal metabolic function, which could increase the risk of obesity in childhood. However, to our knowledge, no epidemiologic study has investigated the association between prenatal exposure to air pollution and indicators of fetal metabolic function. We investigated the association between maternal exposure to nitrogen dioxide and fine particulate matter (aerodynamic diameter ≤2.5 µm) and umbilical cord blood leptin and adiponectin levels with mixed-effects linear regression models among 1,257 mother-infant pairs from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, conducted in Canada (2008-2011). We observed that an interquartile-range increase in average exposure to fine particulate matter (3.2 µg/m(3)) during pregnancy was associated with an 11% (95% confidence interval: 4, 17) increase in adiponectin levels. We also observed 13% (95% confidence interval: 6, 20) higher adiponectin levels per interquartile-range increase in average exposure to nitrogen dioxide (13.6 parts per billion) during pregnancy. Significant associations were seen between air pollution markers and cord blood leptin levels in models that ...Continue Reading

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Citations

Oct 19, 2016·Journal of Occupational and Environmental Medicine·Jillian Ashley-MartinLinda Dodds
Sep 5, 2020·Environmental Epidemiology·Clara G SearsJoseph M Braun
Jan 29, 2019·Current Epidemiology Reports·Izzuddin M ArisEmily Oken
Apr 8, 2021·Environmental Science & Technology·Minjie ChenZhekang Ying
Nov 23, 2021·The Science of the Total Environment·Li ShangMei Chun Chung

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