Air pollution exposure is associated with the gut microbiome as revealed by shotgun metagenomic sequencing.

Environment International
Farnaz FouladiTanya L Alderete

Abstract

Animal work indicates exposure to air pollutants may alter the composition of the gut microbiota. This study examined relationships between air pollutants and the gut microbiome in young adults residing in Southern California. Our results demonstrate significant associations between exposure to air pollutants and the composition of the gut microbiome using whole-genome sequencing. Higher exposure to 24-hour O3 was associated with lower Shannon diversity index, higher Bacteroides caecimuris, and multiple gene pathways, including L-ornithine de novo biosynthesis as well as pantothenate and coenzyme A biosynthesis I. Among other pollutants, higher NO2 exposure was associated with fewer taxa, including higher Firmicutes. The percent variation in gut bacterial composition that was explained by air pollution exposure was up to 11.2% for O3 concentrations, which is large compared to the effect size for many other covariates reported in healthy populations. This study provides the first evidence of significant associations between exposure to air pollutants and the compositional and functional profile of the human gut microbiome. These results identify O3 as an important pollutant that may alter the human gut microbiome.

Citations

Nov 24, 2020·The Science of the Total Environment·Cécile VignalMathilde Body-Malapel
Mar 6, 2021·Bioactive Materials·Rick Xing Ze Lu, Milica Radisic
Sep 20, 2020·Toxicology Letters·Yanfeng XueXiangyang Kong
Apr 4, 2021·Journal of Clinical Medicine·Jorge OjedaPía M Vidal
Jun 7, 2021·Environmental Health : a Global Access Science Source·William B PattersonTanya L Alderete
Jun 22, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christina Jane AdlerChristine Austin
Jul 3, 2021·International Journal of Environmental Research and Public Health·Laura Franza, Rossella Cianci
Oct 13, 2021·MSystems·Travis J De WolfeMaría Rebolleda Gómez

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