Air Pollution Neurotoxicity in the Adult Brain: Emerging Concepts from Experimental Findings.
Abstract
Epidemiological studies are associating elevated exposure to air pollution with increased risk of Alzheimer's disease and other neurodegenerative disorders. In effect, air pollution accelerates many aging conditions that promote cognitive declines of aging. The underlying mechanisms and scale of effects remain largely unknown due to its chemical and physical complexity. Moreover, individual responses to air pollution are shaped by an intricate interface of pollutant mixture with the biological features of the exposed individual such as age, sex, genetic background, underlying diseases, and nutrition, but also other environmental factors including exposure to cigarette smoke. Resolving this complex manifold requires more detailed environmental and lifestyle data on diverse populations, and a systematic experimental approach. Our review aims to summarize the modest existing literature on experimental studies on air pollution neurotoxicity for adult rodents and identify key gaps and emerging challenges as we go forward. It is timely for experimental biologists to critically understand prior findings and develop innovative approaches to this urgent global problem. We hope to increase recognition of the importance of air pollution o...Continue Reading
References
Nervous system effects in rats on subacute exposure by lead-containing nanoparticles via the airways
Intranasal exposure to uranium results in direct transfer to the brain along olfactory nerve bundles
Ozone induces glucose intolerance and systemic metabolic effects in young and aged Brown Norway rats
Measurement techniques for respiratory tract deposition of airborne nanoparticles: a critical review
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