Air Pollution Neurotoxicity in the Adult Brain: Emerging Concepts from Experimental Findings.

Journal of Alzheimer's Disease : JAD
Amin HaghaniCaleb E Finch

Abstract

Epidemiological studies are associating elevated exposure to air pollution with increased risk of Alzheimer's disease and other neurodegenerative disorders. In effect, air pollution accelerates many aging conditions that promote cognitive declines of aging. The underlying mechanisms and scale of effects remain largely unknown due to its chemical and physical complexity. Moreover, individual responses to air pollution are shaped by an intricate interface of pollutant mixture with the biological features of the exposed individual such as age, sex, genetic background, underlying diseases, and nutrition, but also other environmental factors including exposure to cigarette smoke. Resolving this complex manifold requires more detailed environmental and lifestyle data on diverse populations, and a systematic experimental approach. Our review aims to summarize the modest existing literature on experimental studies on air pollution neurotoxicity for adult rodents and identify key gaps and emerging challenges as we go forward. It is timely for experimental biologists to critically understand prior findings and develop innovative approaches to this urgent global problem. We hope to increase recognition of the importance of air pollution o...Continue Reading

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Citations

Feb 14, 2021·Journal of Alzheimer's Disease : JAD·Giulia GrandeDebora Rizzuto
Feb 14, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Caleb E Finch, Amin Haghani
May 11, 2021·Journal of Alzheimer's Disease : JAD·Hongqiao ZhangCaleb E Finch
Aug 26, 2021·Journal of Neurodevelopmental Disorders·Amin HaghaniHeather E Volk

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