Air pollution, particulate matter composition and methylation-based biologic age.

Environment International
Alexandra J WhiteDale P Sandler

Abstract

Epigenetic age, as defined by DNA methylation, may be influenced by air pollution exposure. To evaluate the relationship between NO2, particulate matter (PM), PM components and accelerated epigenetic age. In a sample of non-Hispanic white women living in the contiguous U.S. (n = 2747), we estimated residential exposure to PM2.5, PM10 and NO2 using a model incorporating land-use regression and kriging. Predictive k-means was used to assign participants to clusters representing different PM2.5 component profiles. We measured DNA methylation (DNAm) in blood using the Illumina's Infinium HumanMethylation450 BeadChip and calculated DNAm age using the Hannum, Horvath and Levine epigenetic clocks. Age acceleration was defined based on residuals after regressing DNAm age on chronological age. We estimated associations between interquartile range (IQR) increases in pollutants and age acceleration using linear regression. For PM2.5, we stratified by cluster membership. We examined epigenome-wide associations using robust linear regression models corrected with false discovery rate q-values. NO2 was inversely associated with age acceleration using the Hannum clock (β = -0.24, 95% CI: -0.47, -0.02). No associations were observed for PM10. ...Continue Reading

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Citations

Oct 5, 2019·Nucleic Acids Research·Zhuang XiongYiming Bao
Dec 19, 2019·Aging·Jacob K KresovichJack A Taylor
Oct 10, 2019·Environmental Health Perspectives·Alexandra J WhiteDale P Sandler
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Oct 29, 2020·Journal of Applied Toxicology : JAT·Md Nur AlamQingyu Huang
Nov 12, 2020·Experimental Biology and Medicine·Xi HeJingshan Shi
Mar 7, 2021·International Journal of Molecular Sciences·Omar HahadThomas Münzel
Mar 12, 2021·American Journal of Epidemiology·Jacob K KresovichJack A Taylor
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Apr 15, 2021·Environmental Health : a Global Access Science Source·Matthew R RytelKarl T Kelsey
Jun 19, 2021·Environment International·Paula de Prado-BertMariona Bustamante
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Oct 13, 2021·The American Journal of Clinical Nutrition·Jacob K KresovichJack A Taylor
Feb 23, 2020·Ecotoxicology and Environmental Safety·Quanquan GuanYankai Xia

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Methods Mentioned

BETA
blood draw

Software Mentioned

R
SAS
LASSO
ENmix R

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