Air pollution related prothrombotic changes in persons with diabetes.

Environmental Health Perspectives
Lotte JacobsTim S Nawrot

Abstract

Population studies suggest that persons with diabetes are more sensitive to the effects of particulate matter (PM) air pollution. However, the biological mechanisms of a possible prothrombotic effect underlying this enhanced susceptibility remain largely unknown. We hypothesized that exposure to PM causes prothrombotic changes in persons with diabetes, possibly via systemic inflammation. Our study included 137 nonsmoking adults with diabetes who were outpatients at the University Hospital Leuven. Recent exposure (2 hr before examination) to ambient PM was measured at the entrance of the hospital. Individual chronic exposure to PM was assessed by measuring the area occupied by carbon in airway macrophages obtained by sputum induction. Platelet function was measured ex vivo with the PFA-100 platelet function analyzer, which simulates a damaged blood vessel; we analyzed the function of platelets in primary hemostasis under high shear conditions. Total and differential blood leukocytes were counted. Independent of antiplatelet medication, an interquartile range (IQR) increase of 39.2 microg/m3 in PM10 (PM with aerodynamic diameter <or= 10 microm) concentration measured 2 hr before the clinical examination (recent exposure) was asso...Continue Reading

References

Jan 24, 1998·Metabolism: Clinical and Experimental·J A Colwell
Jun 6, 1998·American Journal of Respiratory Cell and Molecular Biology·J C LayP A Bromberg
Jan 14, 1999·The New England Journal of Medicine·R Ross
Oct 20, 1999·Thorax·A SeatonR Stout
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·H MukaeS F van Eeden
Jun 28, 2001·Environmental Health Perspectives·J Schwartz
Oct 25, 2001·Environmental Health Perspectives·M BrauerA Churg
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·N E AlexisW D Bennett
Mar 7, 2002·JAMA : the Journal of the American Medical Association·C Arden PopeGeorge D Thurston
Mar 19, 2002·Journal of the American College of Cardiology·Tatsushi SuwaStephan F van Eeden
Aug 23, 2002·Epidemiology·Antonella Zanobetti, Joel Schwartz
Oct 4, 2002·The European Respiratory Journal. Supplement·P L PaggiaroP J Sterk
Mar 5, 2003·Circulation·Abderrahim NemmarBenoit Nemery
Jul 2, 2003·Diabetes Care·John A Colwell, Richard W Nesto
Sep 13, 2003·American Journal of Respiratory and Critical Care Medicine·Abderrahim NemmarMarc F Hoylaerts
Dec 4, 2003·Inhalation Toxicology·Andrew J GhioRobert B Devlin
Nov 9, 2004·Environmental Health Perspectives·Elizabeth M FiremanDavid J Prezant
Feb 3, 2005·Environmental Health Perspectives·Nino KünzliHoward N Hodis
May 28, 2005·The Science of the Total Environment·Neeta S KulkarniJonathan Grigg
Jan 18, 2006·JAMA : the Journal of the American Medical Association·Qinghua SunSanjay Rajagopalan
Mar 9, 2006·JAMA : the Journal of the American Medical Association·Francesca DominiciJonathan M Samet
Jul 11, 2006·The New England Journal of Medicine·Neeta KulkarniJonathan Grigg
Aug 9, 2006·European Heart Journal·Anne MaitreRégis de Gaudemaris
Sep 6, 2006·European Heart Journal·Tim S NawrotBenoit Nemery
Jul 20, 2007·Circulation·B HoffmannUNKNOWN Heinz Nixdorf Recall Study Investigative Group
May 13, 2008·Environmental Health Perspectives·Jiu-Chiuan Chen, Joel Schwartz
Aug 23, 2008·Journal of the American College of Cardiology·Boris Z SimkhovichRobert A Kloner
Oct 28, 2008·European Heart Journal·Andrew J LuckingDavid E Newby
Jun 23, 2009·Journal of Thrombosis and Thrombolysis·Nabeel AhmedGraham J Davies

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Citations

May 4, 2010·Environmental Health Perspectives·David Q RichJohn B Kostis
Jun 15, 2011·Environmental Health Perspectives·Moniek ZuurbierBert Brunekreef
May 26, 2012·Environmental Health Perspectives·Bram G JanssenTim S Nawrot
Dec 25, 2013·BMC Public Health·Esmée BijnensTim S Nawrot
Oct 20, 2011·Hämostaseologie·J Emmerechts, M F Hoylaerts
Oct 30, 2010·Journal of Thrombosis and Haemostasis : JTH·J EmmerechtsM F Hoylaerts
Mar 25, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Alberto Dominguez-RodriguezRuben A Juarez-Prera
Oct 5, 2012·Inhalation Toxicology·Mark W FramptonMark J Utell
Jan 22, 2015·Journal of Exposure Science & Environmental Epidemiology·Jaime Mirowsky, Terry Gordon
Jun 15, 2011·Blood·Massimo Franchini, Pier Mannuccio Mannucci
Dec 11, 2014·European Heart Journal·David E NewbyUNKNOWN ESC Heart Failure Association
Dec 17, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Beatriz Fátima Alves de OliveiraSandra Hacon
Jul 21, 2016·Journal of Exposure Science & Environmental Epidemiology·Brent AltemoseJunfeng Zhang
May 19, 2017·Nature Reviews. Cardiology·Simon StewartJohn J V McMurray
Apr 18, 2015·Current Problems in Cardiology·Barry A FranklinC Arden Pope
Sep 2, 2011·Journal of Diabetes Science and Technology·Curtiss B CookMargaret Fowke
Mar 28, 2018·European Journal of Preventive Cardiology·Simone Vidale, Carlo Campana
Jun 20, 2013·Environmental Health Perspectives·Tijs LouwiesTim S Nawrot
Aug 22, 2012·Inhalation Toxicology·Inge BosLuc Int Panis
Feb 2, 2011·PloS One·Lotte JacobsTim S Nawrot
Aug 26, 2011·Inhalation Toxicology·Regina RückerlAnnette Peters
Feb 26, 2014·Thorax·Rossa E BrughaJonathan Grigg
Jul 22, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M C ScarpaP Maestrelli
Jun 12, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S E VerledenB M Vanaudenaerde
Nov 10, 2011·Journal of Thrombosis and Haemostasis : JTH·J EmmerechtsMarc F Hoylaerts
Jul 8, 2017·American Journal of Respiratory and Critical Care Medicine·Nelly D SaenenTim S Nawrot
Dec 7, 2018·Frontiers in Endocrinology·Robert B Hamanaka, Gökhan M Mutlu
May 26, 2017·Antioxidants & Redox Signaling·Simon J WilsonDavid E Newby
Jan 12, 2019·Environmental Science and Pollution Research International·Vida Rezaei HachesuMohammad Javad Zare Sakhvidi
Feb 14, 2019·International Journal of Environmental Health Research·Azis Kemal Fauzie, G V Venkataramana
Feb 23, 2020·Archives of Toxicology·Wenting ChengShuguang Leng

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Methods Mentioned

BETA
light microscopy
blood draw

Software Mentioned

Scion image
SAS
Paint Shop

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