Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor

Biochemical and Biophysical Research Communications
Yuan QiaoWei Liu

Abstract

Accumulating evidence suggests that polycyclic aromatic hydrocarbons (PAH) which adsorbed on the surface of ambient air particulate matters (PM), are the major toxic compound to cause cardiovascular and respiratory diseases, even cancer. However, its detrimental effects on human skin cell remain unclear. Here, we demonstrated that SRM1649b, a reference urban dust material of PAH, triggers human skin cells aging through cell cycle arrest, cell growth inhibition and apoptosis. Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression. Most important, we found that AhR antagonist efficiently revert the aging of skin cells. Thus our novel findings firstly revealed the mechanism of skin aging under PAH contamination and provided potential strategy for clinical application.

Citations

Jul 17, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Danielle HagstromEva-Maria S Collins
Sep 15, 2020·Environmental and Molecular Mutagenesis·Carlotta AliasGiovanna Piovani
Jul 30, 2019·Frontiers in Pharmacology·Concepcion ParradoAngeles Juarranz
Jul 28, 2020·Particle and Fibre Toxicology·Irini M DijkhoffBarbara Rothen-Rutishauser
Jan 30, 2019·BMC Complementary and Alternative Medicine·Minkyung KimEunsun Jung
Nov 19, 2019·Oxidative Medicine and Cellular Longevity·Helen KaiserMark W Hamrick
Dec 22, 2020·Plastic and Reconstructive Surgery·Francesca FerraraGiuseppe Valacchi
Feb 6, 2021·The Journal of Investigative Dermatology·Jean KrutmannMark Berneburg
Jul 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ping DiaoLi Li

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