Airflow pattern complexity during resting breathing in patients with COPD: effect of airway obstruction

Respiratory Physiology & Neurobiology
Karla Kristine DamesPedro Lopes de Melo

Abstract

We investigated the influence of airway obstruction in the complexity of the airflow pattern in COPD and its use as a marker of disease activity. The sample entropy (SampEnV') and the variability (SDV') of the airflow pattern were measured in a group of 88 subjects with various levels of airway obstruction. Airway obstruction resulted in a reduction in the SampEnV' (p<0.0001) that was significantly correlated with spirometric indices of airway obstruction (R=0.50, p<0.001). The early adverse effects in mild airway obstruction were detected by the SampEnV' with an accuracy of 84%. SDV' increased with airway obstruction (p<0.002). We conclude that (1) the airflow patterns in COPD exhibit reduced complexity compared with healthy subjects; (2) this reduction in complexity is proportional to airway obstruction; and (3) the evaluation of SampEnV' may provide novel respiratory biomarkers suitable to facilitate the diagnosis of respiratory abnormalities in COPD.

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Citations

Jan 30, 2016·PloS One·Mohammad Reza RaoufySohrab Hajizadeh
Mar 19, 2016·The European Respiratory Journal·Ville-Pekka SeppäL Pekka Malmberg
Feb 19, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ville-Pekka SeppäJussi Karjalainen
Oct 9, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G B CamiloA J Lopes
Apr 21, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ville-Pekka SeppäGiorgie Petković
Dec 4, 2019·Respiratory Physiology & Neurobiology·Anton HultVille-Pekka Seppä

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