PMID: 9534948Apr 16, 1998Paper

Airway and lung tissue behaviour during endothelin-1 induced constriction in rats: effects of receptor antagonists

Canadian Journal of Physiology and Pharmacology
T NagaseY Ouchi

Abstract

Endothelin (ET) 1, a 21 amino acid constrictor peptide, is one of the most potent agonists of airway smooth muscle and acts on two different receptors, i.e., ETA and ETB receptors. Recently, it has been shown that there are species and organ differences in physiological roles of each ET receptor. In rats, however, the physiological roles of ET receptors remain to be clarified. We questioned whether ET-1 might affect airway and lung tissue via different ET receptor subtypes in rats. To answer this question, we investigated the effects of ET-1 on lung behaviour in anesthetized, open-chested, mechanically ventilated (f = 1 Hz, VT = 9 mL/kg, PEEP = 3 cmH2O (1 cmH2O = 98.1 Pa)) rats in the absence or the presence of ETA and ETB selective antagonists, i.e., BQ-123 and BQ-788, respectively. Using alveolar capsules, we calculated lung elastance (EL), resistance of lung (RL), tissue (Rti), and airway (Raw), and hysteresivity (eta = 2 pifRti/EL) under control conditions and after intravenous administration of ET-1 (10(-8) mol/kg). ET-1 induced significant increases in RL, Rti, Raw, EL, and eta. BQ-123 did not affect ET-1 induced constriction, while BQ-788 significantly reduced delta RL, delta Rti, delta Raw, delta EL during ET-1 induced ...Continue Reading

References

Aug 1, 1991·The American Review of Respiratory Disease·S R WhiteA R Leff
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Citations

Oct 11, 2003·American Journal of Respiratory and Critical Care Medicine·F Javier NietoJohn A Robbins
Oct 11, 2003·American Journal of Respiratory and Critical Care Medicine·Mary S M IpWah-Kit Lam
Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Athanasios G KaditisKonstantinos Gourgoulianis
Nov 3, 2007·American Journal of Respiratory and Critical Care Medicine·David Gozal, Leila Kheirandish-Gozal
Sep 29, 2009·American Journal of Respiratory Cell and Molecular Biology·Philip R CooperR Graham Sturton
Jun 5, 2003·Respiratory Research·Charles G Irvin, Jason H T Bates
May 28, 2004·Toxicology and Applied Pharmacology·David C DormanMelanie F Struve
Mar 29, 2011·Respiratory Physiology & Neurobiology·Brian D KentWalter T McNicholas
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Ivone M FerreiraRoger Goldstein

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