Airway and systemic effects of soluble and suspension formulations of nebulized budesonide in asthmatic children

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Kaninika BasuBrian J Lipworth

Abstract

Using cyclodextrin with budesonide enables it to be formulated in a solution for nebulization. To observe the effects of a Captisol-enabled budesonide solution (CBIS), 60 microg twice daily, delivered via a nebulizer (eFlow), compared with a conventional budesonide suspension (Pulmicort Respules), 250 microg twice daily, delivered via another nebulizer (LC Plus), using fraction of exhaled nitric oxide (FE(NO)) and overnight urinary cortisol to creatinine ratio as the primary outcomes for efficacy and systemic bioactivity. A randomized, open-label, crossover study was conducted in 12 children with mild-to-moderate persistent asthma (aged 5-12 years). Measurements were performed after a 2-week steroid washout at baseline and at the end of each 2-week randomized treatment. The nebulization time was shorter (95% confidence interval [CI], 0.83-5.63 minutes; P = .03) with CBIS (mean, 1.77 minutes) than with Pulmicort Respules (mean, 5.01 minutes). The reduction in FE(NO) with CBIS from pooled baseline was 2.45-fold (95% CI, 1.87-3.21; P < .001); and with Pulmicort Respules, 3.18-fold (95% CI, 2.26-4.47; P < .001). No statistically significant changes from pooled baseline in lung function and overnight urinary cortisol to creatinine r...Continue Reading

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Citations

Oct 26, 2013·Lasers in Medical Science·Xue-yan WangYing-xin Li
Nov 9, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Miguel J LanzStefania Prendes
Dec 15, 2015·Current Opinion in Allergy and Clinical Immunology·Hongfei LouLuo Zhang
Oct 24, 2013·BioMed Research International·Attapon Cheepsattayakorn, Ruangrong Cheepsattayakorn
Dec 9, 2014·The Journal of Allergy and Clinical Immunology·Chengshuo WangLuo Zhang
Jun 24, 2017·Biochimica Et Biophysica Acta. Biomembranes·Andreia G Dos SantosMarie-Paule Mingeot-Leclercq
Jul 4, 2019·Current Allergy and Asthma Reports·Victoria A WickenheisserTeresa Kathleen Tarrant
May 25, 2021·International Journal of Pharmaceutics·Giuseppe Francesco RacanielloNunzio Denora

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