Abstract
The maximal expiratory flow-volume (MEFV) maneuver is a commonly used test of lung function. More detailed interpretation than is currently available might be useful to understand disease better. We propose that a previously published computational model (Lambert RK, Wilson TA, Hyatt RE, and Rodarte JR. J Appl Physiol 52: 44-56, 1982) can be used to deduce, from the MEFV curve, the serial distribution of airway areas in the larger airways. An automated procedure based on the simulated annealing technique was developed. It was tested with model-generated flow data in which airway areas were reduced one generation at a time. The procedure accurately located the constriction and predicted its size within narrow bounds when the constriction was in the six most central generations of airways. More peripheral constrictions were detected but were not precisely located, nor were their sizes accurately evaluated. Airway areas of generations upstream of the constriction were usually overestimated. The procedure was applied to spirometric data obtained from eight volunteers (4 asthmatic and 4 normal subjects) at baseline and after methacholine challenge. The predicted areas show individual differences both in absolute values, and in relat...Continue Reading
References
Sep 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S V Dawson, E A Elliott
Jan 1, 1992·IEEE Transactions on Bio-medical Engineering·J H Bates, A M Lauzon
Jun 1, 1990·Journal of Applied Physiology·R K Lambert
Jul 1, 1988·Journal of Applied Physiology·D EladA H Shapiro
May 1, 1987·Journal of Applied Physiology·J SolwayJ M Drazen
Jun 1, 1987·Journal of Applied Physiology·R K Lambert
Jul 1, 1986·Journal of Applied Physiology·R K Lambert
Jan 1, 1967·Journal of Applied Physiology·J MeadJ B Little
Nov 1, 1967·Journal of Applied Physiology·N B PrideB Bromberger-Barnea
Oct 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R K Lambert
Jan 1, 1981·Annals of Biomedical Engineering·R E HyattR K Lambert
Jan 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R K LambertJ R Rodarte
Jun 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R E HyattE Bar-Yishay
Aug 1, 1994·Journal of Applied Physiology·A BaiM Okazawa
Sep 18, 1997·Journal of Applied Physiology·X ShenS J Gunst
Oct 24, 1997·Journal of Applied Physiology·X ShenR S Tepper
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·J J FredbergS A Shore
Apr 8, 1999·Journal of Applied Physiology·K C BeckP D Scanlon
Jan 18, 2002·Journal of Applied Physiology·Ron C Anafi, Theodore A Wilson
Feb 7, 2003·Journal of Applied Physiology·Ron C AnafiTheodore A Wilson
Aug 16, 2003·Annals of Biomedical Engineering·Adam G Polak, Kenneth R Lutchen
Nov 1, 1958·Journal of Applied Physiology·R E HYATTD L FRY
Oct 1, 1958·Physics in Medicine and Biology·D L FRY
Jan 13, 2004·Journal of Applied Physiology·Rodney K LambertRobert S Tepper
May 13, 1983·Science·S KirkpatrickM P Vecchi
Citations
Aug 28, 2007·Journal of Biomechanics·Vladimir I Korenbaum, Irina A Pochekutova
Sep 11, 2007·Respiratory Physiology & Neurobiology·John R Fitz-Clarke
Apr 7, 2015·Interface Focus·Kerry L HedgesMerryn H Tawhai
Jul 27, 2005·IEEE Transactions on Bio-medical Engineering·Birgit Morlion, Adam G Polak
May 17, 2008·Upsala Journal of Medical Sciences·Antonia Anogeianaki
Jul 5, 2005·Journal of Applied Physiology·Rodney K Lambert, Theodore A Wilson
Jan 14, 2020··Janusz MroczkaAdam G. Polak