Airway distensibility and volume recruitment with lung inflation in COPD

Journal of Applied Physiology
Simonetta BaldiRiccardo Pellegrino

Abstract

The effects of full lung inflation on respiratory conductance (Grs) and reactance (Xrs) were measured in 15 subjects with moderate to severe chronic obstructive pulmonary disease (COPD) and 11 matched healthy control subjects. Airway distensibility was estimated from the ratio of the difference of Grs between functional residual capacity and total lung capacity to the relevant changes in lung volume (ΔGrs/ΔVl) or transpulmonary pressure (ΔGrs/ΔPtp). Similar analysis was applied to Xrs to estimate lung volume recruitment (ΔXrs/ΔVl or ΔXrs/ΔPtp). The extent of emphysema in COPD subjects was estimated from the percentage of low attenuation area (LAA) at high-resolution computed tomography. At baseline, ΔGrs/ΔVl and ΔXrs/ΔVl were significantly less in COPD than control subjects, indicating less distensibility and volume recruitment in the former. In COPD, ΔGrs/ΔPtp and ΔXrs/ΔPtp were uncorrelated with LAA but correlated with 1-s forced expiratory volume and with each other. After albuterol, both ΔGrs/ΔPtp and ΔGrs/ΔVl became significantly and negatively correlated with LAA, while ΔXrs/ΔPtp and ΔXrs/ΔVl decreased significantly independently of LAA. Moreover, ΔGrs/ΔPtp and ΔXrs/ΔPtp with lung inflation were no longer correlated with ...Continue Reading

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Citations

Jun 29, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Gregory G King
Oct 21, 2011·Critical Reviews in Biomedical Engineering·David W Kaczka, Raffaele L Dellacá
Sep 3, 2014·Chest·Riccardo Pellegrino, Vito Brusasco
Sep 27, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Vito BrusascoEmanuele Crimi
Apr 1, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Koichi HasegawaShigeo Muro
Aug 18, 2012·Respiratory Physiology & Neurobiology·Giovanni BarisioneVito Brusasco
Jul 7, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Robyn L JonesAlan L James
Feb 21, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alvenia CairncrossPeter K McFawn
Feb 15, 2019·Journal of Applied Physiology·Stephen MilneGregory G King
Jun 11, 2011·Journal of Applied Physiology·Riccardo PellegrinoVito Brusasco
Feb 1, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Ynuk Bossé

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