PMID: 9543286May 16, 1998Paper

Airway dynamics, oesophageal pressure and cough

The European Respiratory Journal
M H LavietesG C Smaldone

Abstract

This study hypothesizes that: peak supramaximal airflow during cough reflects expiratory muscle effort, and that expiratory muscle function during cough might be assessed from the airflow signal alone. We monitored airflow and oesophageal pressure (Poes) in normal subjects during cough generated under two conditions: 1) voluntarily from functional residual capacity (FRC); and 2) involuntarily after inhalation of citric acid (CA). Maximal expiratory cough flow was quantified as the quotient of maximal flow during a given cough divided by maximal flow at the matched volume of thoracic gas (Vtg) as identified on the maximal expiratory flow-volume curve. We found: flow ratios correlated poorly with Poes; the variance of flow ratios associated with a series of voluntary coughs was poorly explained by Poes. During CA inhalation, when the Vtg compressed during cough could not be controlled, correlation of Poes with flow ratio remained poor. We conclude that to study the motor limb of the cough reflex, measurements of both airflow and oesophageal pressure are required.

Citations

Aug 7, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·M V SzabariB Suki
Dec 7, 2011·The Journal of Physiology·Jaclyn A SmithPeter M Calverley
Apr 12, 2011·The Laryngoscope·Ramon A FrancoIrene E Kochevar
Jul 26, 2013·Neurorehabilitation and Neural Repair·Rachel A McBainJane E Butler
Jan 7, 2010·Therapeutic Advances in Respiratory Disease·Emma C Young, Jaclyn A Smith
Feb 7, 2018·Frontiers in Surgery·Friedrich KallinowskiRegine Nessel
Feb 14, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andreas KirschbaumNikolas Mirow
Dec 3, 2008·Journal of Biomechanical Engineering·Shailesh Naire
Nov 5, 2013·Physiology·Béla SukiErzsébet Bartolák-Suki
Jul 22, 2019·Pulmonary Pharmacology & Therapeutics·Emma WallacePhoebe Macrae

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