Abstract
Endothelins (ETs) are 21 amino acid peptides which, in addition to their other properties, are potent bronchoconstrictors. Whilst there is evidence of the involvement of ET in the pathophysiology of chronic asthma, its contribution to the acute allergic response is undefined. To examine this, we have undertaken segmental bronchoprovocation with allergen and saline at separate sites in six atopic asthmatics receiving treatment with bronchodilators only and six atopic asthmatics additionally receiving treatment with inhaled corticosteroids. Each challenged segment was lavaged 10 min after bronchoprovocation and concentrations of immunoreactive ET were measured in bronchoalveolar lavage fluid. In the non-steroid-treated subjects, there were significantly lower ET levels at the allergen-challenged sites compared to the saline-challenged sites (p<0.05). In the steroid-treated subjects, on the other hand, there was no significant difference between the two sites. Levels of ET at the saline-challenged sites were significantly lower in the steroid-treated subjects compared to the non-steroid-treated subjects (p<0.04). These findings do not support the hypothesis that allergen exposure in asthma results in immediate release of endotheli...Continue Reading
Citations
Apr 6, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·Y KizawaH Murakami
May 7, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yehia El-GamalNahed Boseila
Jun 18, 2003·Current Opinion in Pharmacology·Lynette B Fernandes, Roy G Goldie
Sep 19, 2000·Thorax·A M VignolaG Bonsignore
Apr 20, 2001·Thorax·A E RedingtonJ M Polak
May 2, 2007·The European Respiratory Journal·S S AnL Wang
Nov 2, 2007·Respiratory Research·Ziemowit ZietkowskiAnna Bodzenta-Lukaszyk
Jan 10, 2014·American Journal of Respiratory and Critical Care Medicine·Jens Vogel-ClaussenJens M Hohlfeld
Feb 27, 2004·Biochemical and Biophysical Research Communications·Ping CuiHiroshi Kido
Nov 16, 2005·Pulmonary Pharmacology & Therapeutics·John V Bonacci, Alastair G Stewart
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T Holgate
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H K MakkerS T Holgate
Aug 3, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bo LanJin-Ah Park
Aug 22, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ralph McWhinnieTony R Bai
Mar 14, 2000·The Journal of Pharmacy and Pharmacology·D Spina
Jul 14, 1999·Life Sciences·R G Goldie, P J Henry